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  • Isolation and Structural Elucidation of Bioactive Compounds from Bangladeshi Medicinal Plants with a Focus on Novel Anticancer Compounds

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    Akter_2014_02Thesis.pdf (5.014Mb)
    Author(s)
    Akter, Raushanara
    Primary Supervisor
    Tiralongo, Evelin
    Other Supervisors
    Grice, Darren
    Year published
    2014
    Metadata
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    Abstract
    The present study describes the bioactivity guided isolation and structural elucidation of novel anticancer compounds from the Bangladeshi medicinal plant Blumera lacera. At the outset nineteen Bangladeshi medicinal plants were selected and collected from different parts of Bangladesh. Plants underwent preliminary cytotoxicity screening based on their traditional medicinal uses, limited previous research on them, and their availability. The selected plants were extracted with methanol and screened for their cytotoxic potential using the MTT assay against two healthy cell lines (mouse fibroblast (NIH3T3), a healthy monkey ...
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    The present study describes the bioactivity guided isolation and structural elucidation of novel anticancer compounds from the Bangladeshi medicinal plant Blumera lacera. At the outset nineteen Bangladeshi medicinal plants were selected and collected from different parts of Bangladesh. Plants underwent preliminary cytotoxicity screening based on their traditional medicinal uses, limited previous research on them, and their availability. The selected plants were extracted with methanol and screened for their cytotoxic potential using the MTT assay against two healthy cell lines (mouse fibroblast (NIH3T3), a healthy monkey kidney (VERO)) and four cancer cell lines namely, gastric (AGS), colon (HT-29), two breast (estrogen-dependent: MCF-7 and estrogen non-dependent: MDA-MB-231). Preliminary cytotoxicity assessment led to the identification of seven plants with significant cytotoxic potential, having IC50 < 1.0 mg/mL against a minimum of one cancer cell line. The identified plants were: Avicennia alba, Caesalpinia pulcherrima, Diospyros peregrina, Ecbolium viride, Jasminum sambac, Clitoria terantea, and Saraca asoca. The bioactivity detected correlated with their traditional uses as anticancer agents. Comparing cytotoxicity effects of the selected plants with that of Blumea lacera which was previously screened for cytotoxic potential in our research lab, Blumea lacera was found to be more cytotoxic and thus selected for bioassay-guided isolation of constituents.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Pharmacy
    DOI
    https://doi.org/10.25904/1912/400
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Subject
    Bangladeshi medicinal plants
    Novel Anticancer Compounds
    Blumera lacera
    Avicennia alba
    Caesalpinia pulcherrima
    Diospyros peregrina
    Ecbolium viride
    Jasminum sambac
    Clitoria terantea
    Saraca asoca.
    Plant cytotoxicity
    Publication URI
    http://hdl.handle.net/10072/366507
    Collection
    • Theses - Higher Degree by Research

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