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dc.contributor.advisorTiralongo, Evelin
dc.contributor.authorAkter, Raushanara
dc.date.accessioned2018-01-23T02:30:21Z
dc.date.available2018-01-23T02:30:21Z
dc.date.issued2014
dc.identifier.doi10.25904/1912/400
dc.identifier.urihttp://hdl.handle.net/10072/366507
dc.description.abstractThe present study describes the bioactivity guided isolation and structural elucidation of novel anticancer compounds from the Bangladeshi medicinal plant Blumera lacera. At the outset nineteen Bangladeshi medicinal plants were selected and collected from different parts of Bangladesh. Plants underwent preliminary cytotoxicity screening based on their traditional medicinal uses, limited previous research on them, and their availability. The selected plants were extracted with methanol and screened for their cytotoxic potential using the MTT assay against two healthy cell lines (mouse fibroblast (NIH3T3), a healthy monkey kidney (VERO)) and four cancer cell lines namely, gastric (AGS), colon (HT-29), two breast (estrogen-dependent: MCF-7 and estrogen non-dependent: MDA-MB-231). Preliminary cytotoxicity assessment led to the identification of seven plants with significant cytotoxic potential, having IC50 < 1.0 mg/mL against a minimum of one cancer cell line. The identified plants were: Avicennia alba, Caesalpinia pulcherrima, Diospyros peregrina, Ecbolium viride, Jasminum sambac, Clitoria terantea, and Saraca asoca. The bioactivity detected correlated with their traditional uses as anticancer agents. Comparing cytotoxicity effects of the selected plants with that of Blumea lacera which was previously screened for cytotoxic potential in our research lab, Blumea lacera was found to be more cytotoxic and thus selected for bioassay-guided isolation of constituents.
dc.languageEnglish
dc.publisherGriffith University
dc.publisher.placeBrisbane
dc.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
dc.subject.keywordsBangladeshi medicinal plants
dc.subject.keywordsNovel Anticancer Compounds
dc.subject.keywordsBlumera lacera
dc.subject.keywordsAvicennia alba
dc.subject.keywordsCaesalpinia pulcherrima
dc.subject.keywordsDiospyros peregrina
dc.subject.keywordsEcbolium viride
dc.subject.keywordsJasminum sambac
dc.subject.keywordsClitoria terantea
dc.subject.keywordsSaraca asoca.
dc.subject.keywordsPlant cytotoxicity
dc.titleIsolation and Structural Elucidation of Bioactive Compounds from Bangladeshi Medicinal Plants with a Focus on Novel Anticancer Compounds
dc.typeGriffith thesis
gro.facultyGriffith Health
gro.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
gro.hasfulltextFull Text
dc.contributor.otheradvisorGrice, Darren
dc.rights.accessRightsPublic
gro.identifier.gurtIDgu1443575482947
gro.thesis.degreelevelThesis (PhD Doctorate)
gro.thesis.degreeprogramDoctor of Philosophy (PhD)
gro.departmentSchool of Pharmacy
gro.griffith.authorAkter, Raushanara


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