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dc.contributor.advisorSingh, Indu
dc.contributor.authorSanthakumar, Abishek Bommannan
dc.date.accessioned2018-01-23T02:30:22Z
dc.date.available2018-01-23T02:30:22Z
dc.date.issued2014
dc.identifier.doi10.25904/1912/1314
dc.identifier.urihttp://hdl.handle.net/10072/366508
dc.description.abstractThe metabolic system is one of the most fundamental requirements for precise physiological functioning and survival. The dysfunction of this system can lead to a variety of chronic metabolic disorders such as cardiovascular disease (CVD) and type 2 diabetes (T2DM). According to the National Heart Foundation of Australia, CVD and stroke is the leading cause of death in Australia, with 45,622 deaths in 2011. Oxidative stress plays a central role in the pathogenesis of a wide range of cardiovascular related diseases, including thrombosis, T2DM, hyper-cholesterolaemia and atherosclerosis. Extensive research during the last 25 years has demonstrated that free radicals, particularly, reactive oxygen species and reactive nitrogen species play a cardinal role in the damage caused by oxidative stress. There is increased oxidative stress due to pathological conditions such as T2DM and lifestyle related disorders such as obesity, which impairs muscle glucose uptake, by damaging the blood vessel walls, by oxidising lipids and in turn activating platelets resulting in thrombosis and other cardiac complications.
dc.languageEnglish
dc.publisherGriffith University
dc.publisher.placeBrisbane
dc.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
dc.subject.keywordsCardiovascular disease (CVD)
dc.subject.keywordsType 2 diabetes (T2DM).
dc.subject.keywordsOxidative stress
dc.titleRole of Antioxidants and Polyphenols in Thrombosis and Haemostatic Function
dc.typeGriffith thesis
gro.facultyGriffith Health
gro.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
gro.hasfulltextFull Text
dc.contributor.otheradvisorPerkins, Tony
dc.rights.accessRightsPublic
gro.identifier.gurtIDgu1445302319857
gro.source.ADTshelfnoADT0
gro.source.GURTshelfnoGURT
gro.thesis.degreelevelThesis (PhD Doctorate)
gro.thesis.degreeprogramDoctor of Philosophy (PhD)
gro.departmentSchool of Medical Science
gro.griffith.authorSanthakumar, Abishek B.


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