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  • Investigation of Host-Pathogen Interactions and Interleukin-10 Induction Mediated by Uropathogenic Escherichia coli during Urinary Tract Infection

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    Duell_2014_02Thesis.pdf (31.86Mb)
    Author
    Duell, Benjamin Luke
    Primary Supervisor
    Glen Ulett
    Other Supervisors
    Allan Cripps
    Mark Schembnri
    Year published
    2014
    Metadata
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    Abstract
    Urinary tract infections (UTI) are a major source of morbidity, affecting 50% of women at least once, and sometimes with recurrent episodes. These infections can be localised as cystitis or urethritis, and sometimes develop more severely as pyelonephritis or urosepsis. UTI also affects the elderly and catheterised patients in large numbers. The burden on the health care system arises from more than 8 million UTI-related consultations per year; with health care costs estimated in excess of $3.5 billion, in the USA alone. While UTI is caused by a range of different microbes, the predominant infectious organism is uropathogenic ...
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    Urinary tract infections (UTI) are a major source of morbidity, affecting 50% of women at least once, and sometimes with recurrent episodes. These infections can be localised as cystitis or urethritis, and sometimes develop more severely as pyelonephritis or urosepsis. UTI also affects the elderly and catheterised patients in large numbers. The burden on the health care system arises from more than 8 million UTI-related consultations per year; with health care costs estimated in excess of $3.5 billion, in the USA alone. While UTI is caused by a range of different microbes, the predominant infectious organism is uropathogenic Escherichia coli (UPEC), which accounts for 55 to 85% of UTI cases. UPEC has multiple virulence factors that confer motility, adhesion, invasion, immune evasion, nutrient acquisition and biofilm formation. These virulence traits contribute to the development of UTI to various degrees. The human response to UTI has been characterised in many studies to date that have defined a complex series of biochemical and immunological signalling interactions, incorporating lymphocytes, granulocytes, mononuclear and uroepithelial cells. The research literature on UPEC UTI has focused mainly on discrete virulence factors of the bacteria and specific components of the host response to infection. Some features of UTI such as localisation of infection, severity, persistence, and chronic re-recrudescence are partially understood. However, there are many elements that require further study and there have been few broad-based approaches to deciphering the overall pathogenesis of UPEC UTI. Research projects using wider approaches to document events that occur at specific points during infection can offer insight into previously unknown aspects of critical UTI stages.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Medical Science
    Item Access Status
    Public
    Note
    In order to comply with copyright the article in Chapter 7 has not been published here.
    Subject
    Urinary tract infections (UTI)
    Cystitis
    Urethritis
    Pyelonephritis
    Urosepsis
    Uropathogenic Escherichia coli (UPEC)
    Host-Pathogen interactions
    Publication URI
    http://hdl.handle.net/10072/366580
    Collection
    • Theses - Higher Degree by Research

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