Chemical Diversity of Eremophila Species and Screening Library Generation

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Author(s)
Primary Supervisor
Quinn, Ronald
Other Supervisors
Davis, Rohan
Year published
2012
Metadata
Show full item recordAbstract
This thesis explores two aspects of natural product (NP) chemistry. In part A, the use of NPs as scaffolds in the generation of screening libraries was explored as a valuable way to produce structurally diverse compounds with lead- or drug-like physicochemical parameters. Part B describes the chemical investigations of several species from the under-studied Australian endemic plant genus Eremophila, which was selected for examination as it had high potential to be a source of both new chemistry and of unique scaffolds for screening library production.This thesis explores two aspects of natural product (NP) chemistry. In part A, the use of NPs as scaffolds in the generation of screening libraries was explored as a valuable way to produce structurally diverse compounds with lead- or drug-like physicochemical parameters. Part B describes the chemical investigations of several species from the under-studied Australian endemic plant genus Eremophila, which was selected for examination as it had high potential to be a source of both new chemistry and of unique scaffolds for screening library production.
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Thesis Type
Thesis (PhD Doctorate)
Degree Program
Doctor of Philosophy (PhD)
School
School of Biomolecular and Physical Sciences
Copyright Statement
The author owns the copyright in this thesis, unless stated otherwise.
Item Access Status
Public
Subject
Natural product chemistry
Eremophila sturtii
Plasmodium falciparum