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  • Modulatory Function of miRNA in Human Cancer Angiogenesis

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    Vosgha_2017_01Thesis.pdf (4.320Mb)
    Author(s)
    Vosgha, Haleh
    Primary Supervisor
    Lam, Alfred
    Ariana, Armin
    Other Supervisors
    Smith, Robert
    Year published
    2017
    Metadata
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    Abstract
    A variety of factors such as genetic and epigenetic alterations is known to be involved in initiation and progression of the malignant lesion. microRNA dysregulation is identified as one of the epigenetic changes during cancer development. They play important roles in modulating range of pathways including cell differentiation apoptosis, cell invasion, Epithelial-mesenchymal transition (EMT) and angiogenesis. Angiogenesis is a vital process for cancer survival. The process of angiogenesis in malignancy is initially and mainly promoted by vascular endothelial growth factors (VEGFs). Over-expression of VEGF-A in different ...
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    A variety of factors such as genetic and epigenetic alterations is known to be involved in initiation and progression of the malignant lesion. microRNA dysregulation is identified as one of the epigenetic changes during cancer development. They play important roles in modulating range of pathways including cell differentiation apoptosis, cell invasion, Epithelial-mesenchymal transition (EMT) and angiogenesis. Angiogenesis is a vital process for cancer survival. The process of angiogenesis in malignancy is initially and mainly promoted by vascular endothelial growth factors (VEGFs). Over-expression of VEGF-A in different carcinomas has been reported, and its cross-talk has been described in cancer between angiogenesis and epithelial-to-mesenchymal transition (EMT) process. EMT is a process which generates motile and invasive cells and converts epithelial cells into mesenchymal cells. Subsequently, cells acquire migratory abilities, accumulate resistance to different types of cancer therapies and gain stem-cell like properties.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Medical Science
    DOI
    https://doi.org/10.25904/1912/1060
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Subject
    Angiogenesis
    microRNA dysregulation
    Epithelial-mesenchymal transition (EMT)
    vascular endothelial growth factors (VEGFs)
    Thyroid carcinoma
    Publication URI
    http://hdl.handle.net/10072/366968
    Collection
    • Theses - Higher Degree by Research

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