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  • Examination of Innate and Adaptive Immune Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients with Varying Degrees of Symptom Severity

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    Hardcastle_2015_02Thesis.pdf (5.177Mb)
    Author(s)
    Hardcastle, Sharni L.
    Primary Supervisor
    Marshall-Gradisnik, Sonya
    Other Supervisors
    Brenu, Ekua
    Year published
    2015
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    Abstract
    The immune system has a critical influence on the maintenance of physiological homeostasis. To date, immunological dysfunction, particularly reduced natural killer (NK) cell cytotoxic activity in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients has been consistently observed. CFS/ME is a severely debilitating illness, with no known pathomechanism and diagnosis is made according to symptom specific criteria. CFS/ME is characterised by persistent and unexplained fatigue, alongside a range of symptoms, including: post-exertional neuroimmune exhaustion, neurological, immune, gastrointestinal, genitourinary ...
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    The immune system has a critical influence on the maintenance of physiological homeostasis. To date, immunological dysfunction, particularly reduced natural killer (NK) cell cytotoxic activity in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients has been consistently observed. CFS/ME is a severely debilitating illness, with no known pathomechanism and diagnosis is made according to symptom specific criteria. CFS/ME is characterised by persistent and unexplained fatigue, alongside a range of symptoms, including: post-exertional neuroimmune exhaustion, neurological, immune, gastrointestinal, genitourinary and energy metabolism impairments. However, a symptom specific criterion provides complications for diagnosis, particularly as symptoms may be qualitative. CFS/ME is also a heterogeneous illness, with patients experiencing moderate to severe symptoms. CFS/ME patients with moderate symptoms are those who have reduced mobility and ability to perform their routine daily activities. CFS/ME patients with severe symptoms are usually homebound and/or restricted to a wheelchair. The debilitating nature of CFS/ME creates an economic burden and contributes largely to health resources, affecting CFS/ME patients as well as the wider community. In Australia, the annual cost to the community per CFS/ME patient, with a prevalence rate of 0.2% is $729.3 million (based on 2012 estimates and earlier prevalence studies).
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Medical Science
    DOI
    https://doi.org/10.25904/1912/1904
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Subject
    Physiological homeostasis
    Chronic Fatigue Syndrome
    Myalgic Encephalomyelitis Patients
    Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients
    Publication URI
    http://hdl.handle.net/10072/367042
    Collection
    • Theses - Higher Degree by Research

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