dc.contributor.advisor | Marshall-Gradisnik, Sonya | |
dc.contributor.author | Hardcastle, Sharni Lee | |
dc.date.accessioned | 2018-01-23T02:48:26Z | |
dc.date.available | 2018-01-23T02:48:26Z | |
dc.date.issued | 2015 | |
dc.identifier.doi | 10.25904/1912/1904 | |
dc.identifier.uri | http://hdl.handle.net/10072/367042 | |
dc.description.abstract | The immune system has a critical influence on the maintenance of physiological homeostasis. To date, immunological dysfunction, particularly reduced natural killer (NK) cell cytotoxic activity in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients has been consistently observed. CFS/ME is a severely debilitating illness, with no known pathomechanism and diagnosis is made according to symptom specific criteria. CFS/ME is characterised by persistent and unexplained fatigue, alongside a range of symptoms, including: post-exertional neuroimmune exhaustion, neurological, immune, gastrointestinal, genitourinary and energy metabolism impairments. However, a symptom specific criterion provides complications for diagnosis, particularly as symptoms may be qualitative. CFS/ME is also a heterogeneous illness, with patients experiencing moderate to severe symptoms. CFS/ME patients with moderate symptoms are those who have reduced mobility and ability to perform their routine daily activities. CFS/ME patients with severe symptoms are usually homebound and/or restricted to a wheelchair. The debilitating nature of CFS/ME creates an economic burden and contributes largely to health resources, affecting CFS/ME patients as well as the wider community. In Australia, the annual cost to the community per CFS/ME patient, with a prevalence rate of 0.2% is $729.3 million (based on 2012 estimates and earlier prevalence studies). | |
dc.language | English | |
dc.publisher | Griffith University | |
dc.publisher.place | Brisbane | |
dc.rights.copyright | The author owns the copyright in this thesis, unless stated otherwise. | |
dc.subject.keywords | Physiological homeostasis | |
dc.subject.keywords | Chronic Fatigue Syndrome | |
dc.subject.keywords | Myalgic Encephalomyelitis Patients | |
dc.subject.keywords | Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients | |
dc.title | Examination of Innate and Adaptive Immune Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients with Varying Degrees of Symptom Severity | |
dc.type | Griffith thesis | |
gro.faculty | Griffith Health | |
gro.rights.copyright | The author owns the copyright in this thesis, unless stated otherwise. | |
gro.hasfulltext | Full Text | |
dc.contributor.otheradvisor | Brenu, Ekua | |
dc.rights.accessRights | Public | |
gro.identifier.gurtID | gu1478581790355 | |
gro.source.ADTshelfno | ADT0 | |
gro.source.GURTshelfno | GURT | |
gro.thesis.degreelevel | Thesis (PhD Doctorate) | |
gro.thesis.degreeprogram | Doctor of Philosophy (PhD) | |
gro.department | School of Medical Science | |
gro.griffith.author | Hardcastle, Sharni L. | |