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  • Humpback Whale Cell Lines as an In Vitro Tool for Toxicity Assessment

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    Burkard_2017_01Thesis.pdf (7.372Mb)
    Author(s)
    Burkard, Michael
    Primary Supervisor
    Nash, Susan Bengtson
    Other Supervisors
    Cropp, Roger
    Whitworth, Deanne
    Schirmer, Kristin
    Year published
    2017
    Metadata
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    Abstract
    Persistent Organic Pollutants (POPs) are predominantly anthropogenically-derived chemicals, characterized by their persistence, toxicity, capacity for bioaccumulation and tendency for long-range environmental transport. They have been observed at elevated concentrations in polar environments and biota, including Antarctic foraging humpback whales (Megaptera novaeangliae). Southern hemisphere humpback whales are highly dependent on lipid reserves accumulated during summer feeding to sustain their seasonal migration and associated period of voluntary fasting, the longest known in any mammal. This extreme life-history behaviour ...
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    Persistent Organic Pollutants (POPs) are predominantly anthropogenically-derived chemicals, characterized by their persistence, toxicity, capacity for bioaccumulation and tendency for long-range environmental transport. They have been observed at elevated concentrations in polar environments and biota, including Antarctic foraging humpback whales (Megaptera novaeangliae). Southern hemisphere humpback whales are highly dependent on lipid reserves accumulated during summer feeding to sustain their seasonal migration and associated period of voluntary fasting, the longest known in any mammal. This extreme life-history behaviour has been observed to result in a dramatic increase in blubber POP concentrations and presumed circulating lipophilic POP burdens during times of negative energy balance. Toxicological investigations of the effect of circulating POP burdens are, however, constrained by logistical challenges associated with large cetacean research, and the limitations of existing non-lethal research approaches.This thesis research was designed to develop a humpback whale derived fibroblast cell culture for species-specific assessment of the toxicological impact of priority POPs and other potential stressors.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    Griffith School of Environemnt
    DOI
    https://doi.org/10.25904/1912/492
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Note
    In order to comply with copyright the article in Chapter 2 has not been published here.
    Subject
    Persistent organic pollutants
    Anthropogenically-derived chemicals
    Humpback whales (Megaptera novaeangliae)
    Fibroblast cell culture
    Publication URI
    http://hdl.handle.net/10072/367059
    Collection
    • Theses - Higher Degree by Research

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