Show simple item record

dc.contributor.advisorNash, Susan Bengtson
dc.contributor.authorBurkard, Michael
dc.date.accessioned2018-01-23T02:48:33Z
dc.date.available2018-01-23T02:48:33Z
dc.date.issued2017
dc.identifier.doi10.25904/1912/492
dc.identifier.urihttp://hdl.handle.net/10072/367059
dc.description.abstractPersistent Organic Pollutants (POPs) are predominantly anthropogenically-derived chemicals, characterized by their persistence, toxicity, capacity for bioaccumulation and tendency for long-range environmental transport. They have been observed at elevated concentrations in polar environments and biota, including Antarctic foraging humpback whales (Megaptera novaeangliae). Southern hemisphere humpback whales are highly dependent on lipid reserves accumulated during summer feeding to sustain their seasonal migration and associated period of voluntary fasting, the longest known in any mammal. This extreme life-history behaviour has been observed to result in a dramatic increase in blubber POP concentrations and presumed circulating lipophilic POP burdens during times of negative energy balance. Toxicological investigations of the effect of circulating POP burdens are, however, constrained by logistical challenges associated with large cetacean research, and the limitations of existing non-lethal research approaches.This thesis research was designed to develop a humpback whale derived fibroblast cell culture for species-specific assessment of the toxicological impact of priority POPs and other potential stressors.
dc.languageEnglish
dc.publisherGriffith University
dc.publisher.placeBrisbane
dc.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
dc.subject.keywordsPersistent organic pollutants
dc.subject.keywordsAnthropogenically-derived chemicals
dc.subject.keywordsHumpback whales (Megaptera novaeangliae)
dc.subject.keywordsFibroblast cell culture
dc.titleHumpback Whale Cell Lines as an In Vitro Tool for Toxicity Assessment
dc.typeGriffith thesis
dc.date.embargoEnd2018-03-09
gro.facultyScience, Environment, Engineering and Technology
gro.description.notepublicIn order to comply with copyright the article in Chapter 2 has not been published here.
gro.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
gro.hasfulltextFull Text
dc.contributor.otheradvisorCropp, Roger
dc.contributor.otheradvisorWhitworth, Deanne
dc.contributor.otheradvisorSchirmer, Kristin
gro.identifier.gurtIDgu1499996619755
gro.source.ADTshelfnoADT0
gro.source.GURTshelfnoGURT
gro.thesis.degreelevelThesis (PhD Doctorate)
gro.thesis.degreeprogramDoctor of Philosophy (PhD)
gro.departmentGriffith School of Environemnt
gro.griffith.authorBurkard, Michael


Files in this item

This item appears in the following Collection(s)

Show simple item record