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dc.contributor.advisorItzstein, Mark von
dc.contributor.authorTindale, David James
dc.date.accessioned2018-01-23T02:49:06Z
dc.date.available2018-01-23T02:49:06Z
dc.date.issued2007
dc.identifier.doi10.25904/1912/1763
dc.identifier.urihttp://hdl.handle.net/10072/367100
dc.description.abstractThe human parainfluenza viruses (hPIV) are leading causes of respiratory disease in young children, the immunocompromised and the elderly. All subtypes can cause lower and upper respiratory disease. The surface of human parainfluenzza virus and a number of other paramyxoviruses contains, amongst other biomolecules, a multifunctional glycoprotein known as haemagglutinin-neuraminidase (HN). The HN has three roles in viral pathogenesis; the binding to terminally bound sialic acid residues of cell oligosaccharides, thereby mediating viral attacment to the host cell; the promotion of viral and host cell fusion; and the cleavage of cell surface sialic acids to promote viral elution from host cells. The important role of HN in the viral life-cycle makes it an attractive target for therapeutic intervention. This thesis details an investigation into the design, synthesis and assessment of novel inhibitors of paramyxoviral haemagglutinin-neuraminidase.
dc.languageEnglish
dc.publisherGriffith University
dc.publisher.placeBrisbane
dc.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
dc.subject.keywordsHuman parainfluenza viruses
dc.subject.keywordsRespiratory disease
dc.subject.keywordsCell oligosaccharides
dc.subject.keywordsHaemagglutinin-neuraminidase
dc.titleThe Design, Synthesis and Assessment of Novel Haemagglutinin- Neuraminadase Inhibitors
dc.typeGriffith thesis
gro.facultyScience, Environment, Engineering and Technology
gro.description.notepublicThis thesis has been scanned.
gro.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
gro.hasfulltextFull Text
dc.contributor.otheradvisorDyason, Jeff
dc.contributor.otheradvisorThomson, Robin
dc.rights.accessRightsPublic
gro.identifier.gurtIDgu1325569837390
gro.source.ADTshelfnoADT0
gro.source.GURTshelfnoGURT1105
gro.thesis.degreelevelThesis (PhD Doctorate)
gro.thesis.degreeprogramDoctor of Philosophy (PhD)
gro.departmentInstitute for Glycomics
gro.griffith.authorTindal, David


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