• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Theses
    • Theses - Higher Degree by Research
    • View Item
    • Home
    • Griffith Theses
    • Theses - Higher Degree by Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Regulation of the Human MYC Proximal Promoter by STAT Proteins in Cancer Cells

    Thumbnail
    View/Open
    Ghazawi_2011_02Thesis.pdf (6.685Mb)
    Author
    Ghazawi, Ibtisam
    Primary Supervisor
    Stephen Ralph
    Other Supervisors
    Jiri Neuzil
    Year published
    2011
    Metadata
    Show full item record
    Abstract
    Accumulating evidence has indicated important roles played by Signal Transducer and Activator of Transcription (STAT) molecules, STAT1, STAT3 and STAT5 in the abnormal growth of cancer cells. Associated with these malignant changes, many of the STAT-target genes involved in cell growth regulation also become deregulated in cancer cells. One very important oncogene overexpressed in many cancers is MYC whose gene promoter has previously been found to be STAT regulated. Gene reporter assays provide useful tools for studying the roles of cytokines such as interferon (IFN) and their activation of STAT-dependent promoters. The aims of this study were to: 1) establish luciferase reporter vectors for evaluating STAT-mediated gene regulation; 2) investigate the differential DNA binding of STAT1 versus STAT3 and their sequence recognition and relate this to the regulation of key genes involved in malignancy, such as MYC; and 3) investigate the role of STAT5 in the regulation of the MYC promoter, given preliminary data which indicated STAT5 might be directly involved.
    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Medical Science
    Item Access Status
    Public
    Note
    The Appendices have not been published here.
    Subject
    Signal Transducer and Activator of Transcription (STAT) molecules
    Cancer cells
    Human MYC Proximal Promoter
    STAT-mediated gene regulation
    Publication URI
    http://hdl.handle.net/10072/367113
    Collection
    • Theses - Higher Degree by Research

    Footer

    Social media

    • Facebook
    • Twitter
    • YouTube
    • Instagram
    • Linkedin
    First peoples of Australia
    • Aboriginal
    • Torres Strait Islander

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E

    Tagline

    • Gold Coast
    • Logan
    • Brisbane
    • Australia