The Synthesis and Evaluation of Carbohydrate-Based Probes of Proteins Involved in Viral Pathogenesis
View/ Open
Author(s)
Primary Supervisor
Itzstein, Mark von
Other Supervisors
Thomson, Robin
Dyason, Jeffrey
Year published
2017
Metadata
Show full item recordAbstract
Dengue is the most common arboviral infection globally, and causes significant morbidity, mortality and economic burden. There is currently no vaccine or chemotherapeutic treatment available, and a greater understanding of viral pathogenesis is required so that effective treatments can be developed. The research in this PhD thesis is focused on using carbohydrate-based probes to explore two essential aspects of the dengue virus (DENV) lifecycle; the virus-host cell interaction involved in the viral cell entry process, and the replication of viral RNA. [...]Dengue is the most common arboviral infection globally, and causes significant morbidity, mortality and economic burden. There is currently no vaccine or chemotherapeutic treatment available, and a greater understanding of viral pathogenesis is required so that effective treatments can be developed. The research in this PhD thesis is focused on using carbohydrate-based probes to explore two essential aspects of the dengue virus (DENV) lifecycle; the virus-host cell interaction involved in the viral cell entry process, and the replication of viral RNA. [...]
View less >
View less >
Thesis Type
Thesis (PhD Doctorate)
Degree Program
Doctor of Philosophy (PhD)
School
Institute for Glycomics
Copyright Statement
The author owns the copyright in this thesis, unless stated otherwise.
Subject
Dengue
Arboviral infection
Viral pathogenesis
Carbohydrate-based probes