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  • Heritability and genome-wide linkage of complex diseases in the Norfolk Island population isolate

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    Matovinovic_2012_02Thesis.pdf (1.576Mb)
    Author(s)
    Matovinovic, Elizabeth
    Primary Supervisor
    Griffiths, Lyn
    Other Supervisors
    Lea, Rod
    Year published
    2012
    Metadata
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    Abstract
    Complex diseases such as cardiovascular disease, pterygia, glaucoma, and myopia are caused by polygenic, environmental and lifestyle factors. Studying genetics of complex diseases within population isolates has multiple benefits over studies conducted in single families and unrelated populations. Generally, there is increased power to detect heritable effects. Also, the presence of multiple households within an extended pedigree disentangles confounding environmental variables from true genetic effects. Isolated populations also contain greater potential for identifying underlying causal quantitative trait loci. This thesis ...
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    Complex diseases such as cardiovascular disease, pterygia, glaucoma, and myopia are caused by polygenic, environmental and lifestyle factors. Studying genetics of complex diseases within population isolates has multiple benefits over studies conducted in single families and unrelated populations. Generally, there is increased power to detect heritable effects. Also, the presence of multiple households within an extended pedigree disentangles confounding environmental variables from true genetic effects. Isolated populations also contain greater potential for identifying underlying causal quantitative trait loci. This thesis work focuses on heritability and genome-wide linkage analyses of cardiovascular disease and three eye diseases: pterygia, glaucoma, and myopia in the Norfolk Island population isolate. This study investigates gene-environment interactions of four complex diseases: cardiovascular disease, pterygia, glaucoma, and myopia.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    Medical Science
    DOI
    https://doi.org/10.25904/1912/3056
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Subject
    Cardiovascular disease
    Eye disease
    Pterygia
    Glaucoma
    Myopia
    Publication URI
    http://hdl.handle.net/10072/367214
    Collection
    • Theses - Higher Degree by Research

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