• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Theses
    • Theses - Higher Degree by Research
    • View Item
    • Home
    • Griffith Theses
    • Theses - Higher Degree by Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Natural Product and Fragment-Based Drug Discovery Against Malaria Protein Targets by Native Mass Spectrometry

    Thumbnail
    View/Open
    Pedro_2017_01Thesis.pdf (6.275Mb)
    Author(s)
    Pedro, Liliana
    Primary Supervisor
    Quinn, Ronald
    Brown, Christopher
    Other Supervisors
    Vu, Hoan
    Year published
    2017
    Metadata
    Show full item record
    Abstract
    Malaria control interventions have been effective in reducing malaria incidence and mortality rates globally over the last decade. However, increasing resistance of Plasmodium falciparum (P. falciparum) and Plasmodium vivax (P. vivax), the two most prevalent parasite species, to the most used antimalarial drugs, threatens to halt the progress. Given the current limited arsenal of antimalarial drugs has been inspired by natural product scaffolds, these have the potential to be the source of new and structurally different antimalarial drugs, acting through novel mechanisms of action, that are urgently needed. Translating the ...
    View more >
    Malaria control interventions have been effective in reducing malaria incidence and mortality rates globally over the last decade. However, increasing resistance of Plasmodium falciparum (P. falciparum) and Plasmodium vivax (P. vivax), the two most prevalent parasite species, to the most used antimalarial drugs, threatens to halt the progress. Given the current limited arsenal of antimalarial drugs has been inspired by natural product scaffolds, these have the potential to be the source of new and structurally different antimalarial drugs, acting through novel mechanisms of action, that are urgently needed. Translating the structural and biologically relevant diversity of natural products into an efficient and effective drug development process is, nonetheless, not trivial. Fragment-based drug discovery (FBDD) is a relatively recent and promising approach for drug discovery. It involves the identification of small molecular weight compounds, called fragments, that weakly bind to a biological target and their elaboration through chemical synthesis to produce high affinity and selective drugs. For a rational and effective elaboration process, structural and thermodynamic information are essential.
    View less >
    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Natural Sciences
    DOI
    https://doi.org/10.25904/1912/1424
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Subject
    Malaria control
    Plasmodium falciparum (P. falciparum)
    Plasmodium vivax (P. vivax)
    Fragment-based drug discovery (FBDD)
    Native mass spectrometry
    Publication URI
    http://hdl.handle.net/10072/367370
    Collection
    • Theses - Higher Degree by Research

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander