Show simple item record

dc.contributor.advisorAndrews, Kathy
dc.contributor.authorTran, Thanh Nguyen
dc.date.accessioned2018-01-23T02:53:39Z
dc.date.available2018-01-23T02:53:39Z
dc.date.issued2010
dc.identifier.doi10.25904/1912/2472
dc.identifier.urihttp://hdl.handle.net/10072/367456
dc.description.abstractHistone deacetylases (HDACs) are recognised as potential drug targets for many diseases including cancer, inflammatory diseases and some parasitic diseases including malaria. In eukaryotic cells, these enzymes play an important role in transcriptional regulation through modification of chromatin structure. Inhibitors of mammalian HDAC enzymes including trichostain A and apicidin are active against P. falciparum parasites, however these compounds are not selective for malaria parasites versus normal cell lines. The aims of this study were to examine the antimalarial potential of new hydroxamate-based HDAC inhibitors and to investigate a P. falciparum HDAC, PfHDAC1, as a potential new antimalarial drug target.
dc.languageEnglish
dc.publisherGriffith University
dc.publisher.placeBrisbane
dc.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
dc.subject.keywordsHistone deacetylases
dc.subject.keywordsEukaryotic cells
dc.subject.keywordsInflammatory diseases
dc.subject.keywordsMammalian HDAC enzymes
dc.titlePlasmodium Falciparum Histone Deacetylases as Novel Antimalarial Drug Targets
dc.typeGriffith thesis
gro.facultyGriffith Health
gro.description.notepublicJournal articles have not been published here.
gro.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
gro.hasfulltextFull Text
dc.contributor.otheradvisorGardiner, Donald
dc.rights.accessRightsPublic
gro.identifier.gurtIDgu1334640231718
gro.source.ADTshelfnoADT0
gro.source.GURTshelfnoGURT1121
gro.thesis.degreelevelThesis (PhD Doctorate)
gro.thesis.degreeprogramDoctor of Philosophy (PhD)
gro.departmentSchool of Health Science
gro.griffith.authorTran, Thanh


Files in this item

This item appears in the following Collection(s)

Show simple item record