• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Theses
    • Theses - Higher Degree by Research
    • View Item
    • Home
    • Griffith Theses
    • Theses - Higher Degree by Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Structural and Functional Comparisons of Human and Zebrafish Galectin-1

    Thumbnail
    View/Open
    Cozier, Matthew Final Thesis_redacted.pdf (39.37Mb)
    Author(s)
    Cozier, Matthew O.
    Primary Supervisor
    Ralph, Stephen
    Other Supervisors
    Day, Christopher
    Year published
    2016
    Metadata
    Show full item record
    Abstract
    Galectin-1 (Gal-1) is canonically referred to as a ‘galactose-binding lectin’ with several mportant functional and structural characteristics in the immune system. As a target for pharmaceutical research that is gaining in its significance for cancer biology, it is surprising that studies have not focused on Gal-1 structures outside of the mammalian taxa. For this reason, a recombinant Zebrafish Galectin-1 (zGal-1) was utilised as a novel homologous model for hGal-1. On determining the zGal-1 3D structure, several insights were gained through a range of biochemical, biophysical and computational techniques. The results ...
    View more >
    Galectin-1 (Gal-1) is canonically referred to as a ‘galactose-binding lectin’ with several mportant functional and structural characteristics in the immune system. As a target for pharmaceutical research that is gaining in its significance for cancer biology, it is surprising that studies have not focused on Gal-1 structures outside of the mammalian taxa. For this reason, a recombinant Zebrafish Galectin-1 (zGal-1) was utilised as a novel homologous model for hGal-1. On determining the zGal-1 3D structure, several insights were gained through a range of biochemical, biophysical and computational techniques. The results showed similarities between structural characteristics of the reduced forms of hGal-1 and zGal-1. A collection of glycan array data by in-house analysis and analysis of internet databases was also undertaken to evaluate the similarities and differences across vertebrate Galectins. Gal-1 binding glycan array profiles indicated its strong panhomologous affinity for numerous fucosylated and sulphated glycans.
    View less >
    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Medical Science
    DOI
    https://doi.org/10.25904/1912/3207
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Subject
    Human Galectin-1
    Zebrafish Galectin-1
    Galectin-1 (Gal-1)
    Galactose-binding lectin
    Cancer biology
    Publication URI
    http://hdl.handle.net/10072/367618
    Collection
    • Theses - Higher Degree by Research

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E
    • TEQSA: PRV12076

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander