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  • Bioactive Constituents from Traditional Chinese Medicines Targeting Neurodegenerative Diseases

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    Tang_2017_01Thesis.pdf (26.73Mb)
    Author(s)
    Tang, Chunping
    Primary Supervisor
    Quinn, Ronald
    Other Supervisors
    Feng, Yun
    Ye, Yang
    Year published
    2017
    Metadata
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    Abstract
    This thesis described a proof-of-concept to translate ancient traditional Chinese medicines to modern drugs. Taking TCMs targeting neurodegenerative diseases, the thesis presented a data mining of ancient literature, physicochemical analysis of known drugs and TCM compounds, and chemical analysis, and phenotypic screening of TCM extracts, fractions and compounds, and early development of a target identification method. Chapter 1 started with an introduction of traditional Chinese medicines and neurodegenerative diseases. It pointed out that the formula is the essence of TCM, and that herb pairs are a starting point of many ...
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    This thesis described a proof-of-concept to translate ancient traditional Chinese medicines to modern drugs. Taking TCMs targeting neurodegenerative diseases, the thesis presented a data mining of ancient literature, physicochemical analysis of known drugs and TCM compounds, and chemical analysis, and phenotypic screening of TCM extracts, fractions and compounds, and early development of a target identification method. Chapter 1 started with an introduction of traditional Chinese medicines and neurodegenerative diseases. It pointed out that the formula is the essence of TCM, and that herb pairs are a starting point of many formulas. It summarized the natural products used for the treatment of neurodegenerative diseases. It presented an unmet medical need that required new therapeutics. It provided a foundation for the further investigations.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Natural Sciences
    DOI
    https://doi.org/10.25904/1912/2322
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Subject
    Traditional Chinese medicines
    Neurodegenerative diseases
    Publication URI
    http://hdl.handle.net/10072/367626
    Collection
    • Theses - Higher Degree by Research

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