Bioactive Constituents from Traditional Chinese Medicines Targeting Neurodegenerative Diseases
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Author(s)
Primary Supervisor
Quinn, Ronald
Other Supervisors
Feng, Yun
Ye, Yang
Year published
2017
Metadata
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This thesis described a proof-of-concept to translate ancient traditional Chinese medicines to modern drugs. Taking TCMs targeting neurodegenerative diseases, the thesis presented a data mining of ancient literature, physicochemical analysis of known drugs and TCM compounds, and chemical analysis, and phenotypic screening of TCM extracts, fractions and compounds, and early development of a target identification method.
Chapter 1 started with an introduction of traditional Chinese medicines and neurodegenerative diseases. It pointed out that the formula is the essence of TCM, and that herb pairs are a starting point of many ...
View more >This thesis described a proof-of-concept to translate ancient traditional Chinese medicines to modern drugs. Taking TCMs targeting neurodegenerative diseases, the thesis presented a data mining of ancient literature, physicochemical analysis of known drugs and TCM compounds, and chemical analysis, and phenotypic screening of TCM extracts, fractions and compounds, and early development of a target identification method. Chapter 1 started with an introduction of traditional Chinese medicines and neurodegenerative diseases. It pointed out that the formula is the essence of TCM, and that herb pairs are a starting point of many formulas. It summarized the natural products used for the treatment of neurodegenerative diseases. It presented an unmet medical need that required new therapeutics. It provided a foundation for the further investigations.
View less >
View more >This thesis described a proof-of-concept to translate ancient traditional Chinese medicines to modern drugs. Taking TCMs targeting neurodegenerative diseases, the thesis presented a data mining of ancient literature, physicochemical analysis of known drugs and TCM compounds, and chemical analysis, and phenotypic screening of TCM extracts, fractions and compounds, and early development of a target identification method. Chapter 1 started with an introduction of traditional Chinese medicines and neurodegenerative diseases. It pointed out that the formula is the essence of TCM, and that herb pairs are a starting point of many formulas. It summarized the natural products used for the treatment of neurodegenerative diseases. It presented an unmet medical need that required new therapeutics. It provided a foundation for the further investigations.
View less >
Thesis Type
Thesis (PhD Doctorate)
Degree Program
Doctor of Philosophy (PhD)
School
School of Natural Sciences
Copyright Statement
The author owns the copyright in this thesis, unless stated otherwise.
Subject
Traditional Chinese medicines
Neurodegenerative diseases