Botryllamides K and L, new tyrosine derivatives from the Australian ascidian Aplidium altarium
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Chemical investigation of the Australian ascidian Aplidium altarium led to the isolation of two new tyrosine derivatives, botryllamides K (1) and L (2), together with six known metabolites, botryllamides A-C (3-5), botryllamide G (6) and perspicamides A (7) and B (8). The structures of these compounds were elucidated by spectroscopic analysis. This is the first reported chemistry from this species. Compounds 1-8 were evaluated for their cytotoxicity towards the tumour cell lines, MCF-7 (breast), H460 (lung) and SF268 (central nervous system).
Natural Products Chemistry