Comparison of Foreign Body Giant Cells and Osteoclasts and the Role of CCL2, CCR2 and OC-STAMP in their Formation

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Author(s)
Primary Supervisor
Morrison, Nigel
Other Supervisors
Forwood, Mark
Year published
2010
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Multinucleated giant cells (MGCs) are produced by the fusion of white blood cells. Each resultant MGC suggests a specific condition and may even signify associated diseases. These cells are problematic when associated with osteoporosis, arthritis, and implant rejection. Some of the important multinucleated giant cells are explained below.
Osteoclasts are cells that dissolve bone. They are very active in normal bone growth phases, where they give proper shape to the bone along with osteoblasts, which are the bone forming cells. Osteoclasts are responsible for bone degradation and the subsequent reduction of bone density. ...
View more >Multinucleated giant cells (MGCs) are produced by the fusion of white blood cells. Each resultant MGC suggests a specific condition and may even signify associated diseases. These cells are problematic when associated with osteoporosis, arthritis, and implant rejection. Some of the important multinucleated giant cells are explained below. Osteoclasts are cells that dissolve bone. They are very active in normal bone growth phases, where they give proper shape to the bone along with osteoblasts, which are the bone forming cells. Osteoclasts are responsible for bone degradation and the subsequent reduction of bone density. These cells are very active in diseases that cause reduced bone density. Foreign body giant cells (FBGC) are found at foreign body sites including stitches and various implants such as oral, breast and bone implants. Furthermore, these giant cells form around organ transplant sites and in some pathological diseases including tumours.
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View more >Multinucleated giant cells (MGCs) are produced by the fusion of white blood cells. Each resultant MGC suggests a specific condition and may even signify associated diseases. These cells are problematic when associated with osteoporosis, arthritis, and implant rejection. Some of the important multinucleated giant cells are explained below. Osteoclasts are cells that dissolve bone. They are very active in normal bone growth phases, where they give proper shape to the bone along with osteoblasts, which are the bone forming cells. Osteoclasts are responsible for bone degradation and the subsequent reduction of bone density. These cells are very active in diseases that cause reduced bone density. Foreign body giant cells (FBGC) are found at foreign body sites including stitches and various implants such as oral, breast and bone implants. Furthermore, these giant cells form around organ transplant sites and in some pathological diseases including tumours.
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Thesis Type
Thesis (PhD Doctorate)
Degree Program
Doctor of Philosophy (PhD)
School
School of Medical Science
Copyright Statement
The author owns the copyright in this thesis, unless stated otherwise.
Item Access Status
Public
Note
In order to comply with copyright Chapter 6 has not been published here.
Subject
Osteoclasts
Multinucleated giant cells (MGCs)
Foreign body giant cells (FBGC)