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  • Comparison of Foreign Body Giant Cells and Osteoclasts and the Role of CCL2, CCR2 and OC-STAMP in their Formation

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    Khan_2014_02Thesis.pdf (2.222Mb)
    Author(s)
    Khan, Arbab Usman
    Primary Supervisor
    Morrison, Nigel
    Other Supervisors
    Forwood, Mark
    Year published
    2010
    Metadata
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    Abstract
    Multinucleated giant cells (MGCs) are produced by the fusion of white blood cells. Each resultant MGC suggests a specific condition and may even signify associated diseases. These cells are problematic when associated with osteoporosis, arthritis, and implant rejection. Some of the important multinucleated giant cells are explained below. Osteoclasts are cells that dissolve bone. They are very active in normal bone growth phases, where they give proper shape to the bone along with osteoblasts, which are the bone forming cells. Osteoclasts are responsible for bone degradation and the subsequent reduction of bone density. ...
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    Multinucleated giant cells (MGCs) are produced by the fusion of white blood cells. Each resultant MGC suggests a specific condition and may even signify associated diseases. These cells are problematic when associated with osteoporosis, arthritis, and implant rejection. Some of the important multinucleated giant cells are explained below. Osteoclasts are cells that dissolve bone. They are very active in normal bone growth phases, where they give proper shape to the bone along with osteoblasts, which are the bone forming cells. Osteoclasts are responsible for bone degradation and the subsequent reduction of bone density. These cells are very active in diseases that cause reduced bone density. Foreign body giant cells (FBGC) are found at foreign body sites including stitches and various implants such as oral, breast and bone implants. Furthermore, these giant cells form around organ transplant sites and in some pathological diseases including tumours.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Medical Science
    DOI
    https://doi.org/10.25904/1912/2343
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Note
    In order to comply with copyright Chapter 6 has not been published here.
    Subject
    Osteoclasts
    Multinucleated giant cells (MGCs)
    Foreign body giant cells (FBGC)
    Publication URI
    http://hdl.handle.net/10072/367698
    Collection
    • Theses - Higher Degree by Research

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