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dc.contributor.advisorMorrison, Nigel
dc.contributor.authorKhan, Arbab Usman
dc.date.accessioned2018-01-23T02:55:31Z
dc.date.available2018-01-23T02:55:31Z
dc.date.issued2010
dc.identifier.doi10.25904/1912/2343
dc.identifier.urihttp://hdl.handle.net/10072/367698
dc.description.abstractMultinucleated giant cells (MGCs) are produced by the fusion of white blood cells. Each resultant MGC suggests a specific condition and may even signify associated diseases. These cells are problematic when associated with osteoporosis, arthritis, and implant rejection. Some of the important multinucleated giant cells are explained below. Osteoclasts are cells that dissolve bone. They are very active in normal bone growth phases, where they give proper shape to the bone along with osteoblasts, which are the bone forming cells. Osteoclasts are responsible for bone degradation and the subsequent reduction of bone density. These cells are very active in diseases that cause reduced bone density. Foreign body giant cells (FBGC) are found at foreign body sites including stitches and various implants such as oral, breast and bone implants. Furthermore, these giant cells form around organ transplant sites and in some pathological diseases including tumours.
dc.languageEnglish
dc.publisherGriffith University
dc.publisher.placeBrisbane
dc.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
dc.subject.keywordsOsteoclasts
dc.subject.keywordsMultinucleated giant cells (MGCs)
dc.subject.keywordsForeign body giant cells (FBGC)
dc.titleComparison of Foreign Body Giant Cells and Osteoclasts and the Role of CCL2, CCR2 and OC-STAMP in their Formation
dc.typeGriffith thesis
gro.description.notepublicIn order to comply with copyright Chapter 6 has not been published here.
gro.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
gro.hasfulltextFull Text
dc.contributor.otheradvisorForwood, Mark
dc.rights.accessRightsPublic
gro.identifier.gurtIDgu1446089757179
gro.thesis.degreelevelThesis (PhD Doctorate)
gro.thesis.degreeprogramDoctor of Philosophy (PhD)
gro.departmentSchool of Medical Science
gro.griffith.authorKhan, Arbab Usman


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