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  • Decellularized Tissue Engineered Constructs Using Cell Sheet Technology

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    Farag_2016_01Thesis.pdf (3.297Mb)
    Author(s)
    Farag, Amro
    Primary Supervisor
    Ivanovski, Saso
    Other Supervisors
    Hamlet, Stephen
    Hutmacher, Dietmar
    Hashimi, Saeed
    Year published
    2016
    Metadata
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    Abstract
    The periodontium is a complex structure that is comprised of soft tissue components the gingiva and periodontal ligament, as well as hard tissue components in the form of alveolar bone and cementum. Human periodontal ligament cells (HPDLCs) and their extracellular matrix are regarded as essential components to achieve successful periodontal regeneration when treating periodontal lesions. In the present study, cell sheet technology was utilized to fabricate periodontal ligament cell sheets. These cell sheets were subsequently decellularized to isolate and preserve the extracellular component structural and functional ...
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    The periodontium is a complex structure that is comprised of soft tissue components the gingiva and periodontal ligament, as well as hard tissue components in the form of alveolar bone and cementum. Human periodontal ligament cells (HPDLCs) and their extracellular matrix are regarded as essential components to achieve successful periodontal regeneration when treating periodontal lesions. In the present study, cell sheet technology was utilized to fabricate periodontal ligament cell sheets. These cell sheets were subsequently decellularized to isolate and preserve the extracellular component structural and functional characteristics, and were evaluated in vitro and in vivo. In all experiments that were undertaken in this study, melt electro-spun polycaprolactone (PCL) scaffolds were used as a carrier for the cell sheets, in order to support their fragile nature during the processes of decellularization. The combined cell sheet-PCL scaffold structure is referred to as a decellularized cell sheet construct.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Dentistry and Oral Health
    DOI
    https://doi.org/10.25904/1912/2310
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Subject
    Periodontium
    gingiva ligament
    periodontal ligament
    Alveolar bone
    Human periodontal ligament cells (HPDLCs)
    Cell sheet-PCL scaffold structure
    Publication URI
    http://hdl.handle.net/10072/367720
    Collection
    • Theses - Higher Degree by Research

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