Caelestines A-D, brominated quinolinecarboxylic acids from the Australian ascidian aplidium caelestis
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Four new brominated natural products, caelestines A-D (1-4), have been isolated from the Australian ascidian Aplidium caelestis. The structures of 1-4 were determined by analysis of their NMR and MS data. This is the first report of brominated quinolinecarboxylic acids from nature. Compound 1 has been previously synthesized but not spectroscopically characterized. Compounds 1-4 were tested against three mammalian cell lines (MCF-7, NFF, and MM96L) and a panel of microbial strains and showed only minor cytotoxicity.
Journal of Natural Products
This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Natural Products, copyright 2010 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np100329w.
Natural Products Chemistry