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  • Detection and Genotyping of HHV-8 in Australia and Kenya: Disease Associations with Special reference to Kaposi's Sarcoma and Castleman's Disease

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    Speicher_2012_01Abstract.pdf (1.124Mb)
    Speicher_2012_02Thesis.pdf (23.85Mb)
    Author(s)
    Speicher, David J.
    Primary Supervisor
    Johnson, Newell
    Lam, Alfred
    Other Supervisors
    Chuah, John
    Faoagali, Joan
    Year published
    2012
    Metadata
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    Abstract
    HHV-8, the aetiological agent of Kaposi’s sarcoma (KS), multicentric Castleman’s disease (MCD) and primary effusion lymphoma (PEL) has been characterised in several parts of the world but largely overlooked in Australia, perhaps because highly active antiretroviral therapy (HAART) has drastically reduced the incidence of HHV-8-associated diseases in the most at-risk population, namely those with HIV disease. Previously, Australian researchers have looked briefly at the sexual behaviours associated with risk of transmission of HHV-8, at molecular methods for detecting the presence of this virus, and have genotyped just eight ...
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    HHV-8, the aetiological agent of Kaposi’s sarcoma (KS), multicentric Castleman’s disease (MCD) and primary effusion lymphoma (PEL) has been characterised in several parts of the world but largely overlooked in Australia, perhaps because highly active antiretroviral therapy (HAART) has drastically reduced the incidence of HHV-8-associated diseases in the most at-risk population, namely those with HIV disease. Previously, Australian researchers have looked briefly at the sexual behaviours associated with risk of transmission of HHV-8, at molecular methods for detecting the presence of this virus, and have genotyped just eight clinical isolates. Now, the re-emergence of HHV-8 disease associated with increased lifespan in HIV-positive individuals has created a need to better understand the biological importance of this virus, including in Australia and in the developing world. While report of KS and HHV-8 have been previously published from Australia, this project establishes the first research group devoted to the understanding of HHV-8 from an Australian perspective, develops validated quantitative molecular detection methods for HHV-8 in blood and oral fluids, and then characterises the viruses detected via phylogenetic analyses.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Dentistry and Oral Health
    DOI
    https://doi.org/10.25904/1912/1127
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Subject
    HHV-8
    Kaposi’s sarcoma (KS)
    Multicentric Castleman’s disease (MCD)
    Primary effusion lymphoma (PEL)
    Xeroderma pigmentosum
    Publication URI
    http://hdl.handle.net/10072/367862
    Collection
    • Theses - Higher Degree by Research

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