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  • The Antiviral Properties of Melaleuca alternifolia concentrate (MAC) against West Nile virus

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    Pliego-Zamora_2015_02Thesis.pdf (8.558Mb)
    Author(s)
    Pliego-Zamora, Adriana C.
    Primary Supervisor
    Ralph, Steve
    Other Supervisors
    Morrison, Nigel
    Wong, Victor
    Year published
    2015
    Metadata
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    Abstract
    Many Flaviviruses are mosquito-borne viruses that can causes disease in humans and animals including Dengue virus (DENV), West Nile virus (WNV), yellow fever virus (YFV), Japanese encephalitis virus (JEV) and tick-borne encephalitis virus (TBEV). These viruses are highly pathogenic to humans causing extensive morbidity and mortality and most importantly, their recent re-emergence and global spread is a current growing public health issue. Currently, DENV alone causes an approximate 50 million infection cases annually and WNV infections have been reported in the five continents. Despite the existence of licensed vaccines for ...
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    Many Flaviviruses are mosquito-borne viruses that can causes disease in humans and animals including Dengue virus (DENV), West Nile virus (WNV), yellow fever virus (YFV), Japanese encephalitis virus (JEV) and tick-borne encephalitis virus (TBEV). These viruses are highly pathogenic to humans causing extensive morbidity and mortality and most importantly, their recent re-emergence and global spread is a current growing public health issue. Currently, DENV alone causes an approximate 50 million infection cases annually and WNV infections have been reported in the five continents. Despite the existence of licensed vaccines for YFV, JEV and TBEV, a major challenge remains given there are no specific and effective antiviral therapies against flaviviral infections. Considering the homologies between flaviviral replication strategies, it may be possible to identify broad-spectrum compounds with both prophylactic and therapeutic activity against different flavivirus strains. Because the steps involved in compound discovery to their clinical use are protracted and expensive, studies should include testing existing clinically approved drugs as antivirals. Melaleuca alternifolia extracts are good candidates to be explored for novel uses as they have been extensively studied and their composition, chemistry, safety and toxicity are well documented. Melaleluca alternifolia concentrate (MAC) is obtained from the further purification of Tea Tree Oil (TTO) and is a new product exhibiting promising antimicrobial and anti-cancer activities.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Medical Science
    DOI
    https://doi.org/10.25904/1912/2151
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Subject
    Flaviviruses
    Mosquito-borne viruses
    Dengue virus (DENV)
    West Nile virus (WNV)
    Yellow fever virus (YFV),
    Japanese encephalitis virus (JEV)
    Tick-borne encephalitis virus (TBEV)
    Melaleuca alternifolia concentrate (MAC)
    Antivirals
    Publication URI
    http://hdl.handle.net/10072/367888
    Collection
    • Theses - Higher Degree by Research

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