Show simple item record

dc.contributor.advisorYoung, David
dc.contributor.authorSwan, Leesa Michelle
dc.date.accessioned2018-01-23T02:57:51Z
dc.date.available2018-01-23T02:57:51Z
dc.date.issued2009
dc.identifier.doi10.25904/1912/3327
dc.identifier.urihttp://hdl.handle.net/10072/367931
dc.description.abstractPreliminary studies have revealed that the 4-hydroxyphenethyl halides possess the minimal structural requirements needed to mimic the DNA alkylation profile characteristic to seco-CPI subunits. Subsequent assessment of the 4-aminophenethyl halides showed that these adducts exhibit approximately four times the in vitro cytotoxicity demonstrated by their phenolic counterparts. The incorporation of these simpler compounds into more complex molecules containing non-covalent binding subunits was expected to increase both cytotoxicity and sequence selectivity. Biological assessment of the synthesized compounds established that the simplest compound, 4-aminophenethyl bromide, was a potent antitumor drug which exhibited selectivity for tumor cells over normal fibroblastic cells. This makes 4-aminophenethyl bromide an interesting candidate for further in vivo assessment.
dc.languageEnglish
dc.publisherGriffith University
dc.publisher.placeBrisbane
dc.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
dc.subject.keywordsDNA
dc.subject.keywordsDNA alkylating antitumor agents
dc.subject.keywords4-aminophenethyl bromide
dc.subject.keywords4-hydroxyphenethyl halide
dc.subject.keywordstumor cells
dc.subject.keywordsfibroblastic cells
dc.subject.keywordsantitumor drugs
dc.titleThe Development of New DNA Alkylating Antitumour Agents Modeled on the Natural Product CC-1065
dc.typeGriffith thesis
gro.facultyScience, Environment, Engineering and Technology
gro.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
gro.hasfulltextFull Text
dc.contributor.otheradvisorLoughlin, Wendy
dc.rights.accessRightsPublic
gro.identifier.gurtIDgu1316650027846
gro.identifier.ADTnumberadt-QGU20100617.145417
gro.source.ADTshelfnoADT0736
gro.thesis.degreelevelThesis (PhD Doctorate)
gro.thesis.degreeprogramDoctor of Philosophy (PhD)
gro.departmentSchool of Biomolecular and Physical Sciences
gro.griffith.authorSwan, Leesa Michelle


Files in this item

This item appears in the following Collection(s)

Show simple item record