• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Theses
    • Theses - Higher Degree by Research
    • View Item
    • Home
    • Griffith Theses
    • Theses - Higher Degree by Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Targeting Vascular Genes Profile in Thyroid Cancer

    Thumbnail
    View/Open
    Salajegheh_2011_02Thesis .pdf (4.025Mb)
    Author
    Salajegheh, Ali
    Primary Supervisor
    Robert Smith
    Alfred Lam
    Year published
    2011
    Metadata
    Show full item record
    Abstract
    Thyroid cancer is the most common endocrine cancer in the world. This malignancy occurs primarily in young and middle aged adults, with approximately 122,000 new cases per year worldwide. The most common type of thyroid malignancy is papillary thyroid carcinoma (PTC), accounting for approximately three quarters of cases. Spreading of cancer and cancer recurrence after surgery in PTC is principally via lymph node (LN) metastases. Thus, management of patients with thyroid cancer requires a better understanding of the underlying molecular mechanisms of lymphovascular spread of the tumour. The high incidence of LN metastases in ...
    View more >
    Thyroid cancer is the most common endocrine cancer in the world. This malignancy occurs primarily in young and middle aged adults, with approximately 122,000 new cases per year worldwide. The most common type of thyroid malignancy is papillary thyroid carcinoma (PTC), accounting for approximately three quarters of cases. Spreading of cancer and cancer recurrence after surgery in PTC is principally via lymph node (LN) metastases. Thus, management of patients with thyroid cancer requires a better understanding of the underlying molecular mechanisms of lymphovascular spread of the tumour. The high incidence of LN metastases in thyroid cancer thus makes it a potentially useful model to study angiogenic mechanisms common to many cancer types. The follicular variant of papillary thyroid carcinoma (FVPTC) presents a type of papillary thyroid cancer that has created continuous diagnosis and treatment controversies among clinicians and pathologists. This research has described the nomenclature, the clinical features, diagnostic problems and the molecular biology of FVPTC. It is important for clinicians to understand this entity as the diagnosis and management of this group of patient may be different from other patients with conventional PTC (CPTC). The literature suggests that FVPTC behaves in a way similar, clinically, to conventional papillary thyroid carcinoma. However, there are some genotypic differences which may characterise this neoplasm. These parameters may account for the phenotypic variation described by some scientists in this type of cancer. Further understanding can only be achieved by defining strict pathological criteria, in-depth study of the molecular biology and long term follow-up of the optional patients with FVPTC.
    View less >
    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Medicine
    Item Access Status
    Public
    Subject
    Thyroid cancer
    Endocrine cancer
    Papillary thyroid carcinoma
    Publication URI
    http://hdl.handle.net/10072/367959
    Collection
    • Theses - Higher Degree by Research

    Footer

    Social media

    • Facebook
    • Twitter
    • YouTube
    • Instagram
    • Linkedin
    First peoples of Australia
    • Aboriginal
    • Torres Strait Islander

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E

    Tagline

    • Gold Coast
    • Logan
    • Brisbane
    • Australia