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  • Novel Treatment of Breast and Prostate Cancer, and Mesothelioma by Targeting Cancer Stem Cells

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    Zobalova_2013_02Thesis.pdf (2.000Mb)
    Author(s)
    Zobalova, Renata
    Primary Supervisor
    Ralph, Steve
    Other Supervisors
    Peak, Ian
    Year published
    2013
    Metadata
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    Abstract
    Cancer is a major cause of death in the western world and is becoming an increasing world-wide problem. Even though treatment and therapeutic approaches to cancer have become better and there has been great improvement in the diagnosis of this group of pathologies, many cancer types are still lethal as there is no substantial treatment available. Further, even if treatment is successful, there is a significant risk of tumour recurrence, and such a tumour is then even harder to treat due to the acquired resistance in response to exposure to the initial treatment used. Cancer stem cells (CSCs) have been suggested as a reason ...
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    Cancer is a major cause of death in the western world and is becoming an increasing world-wide problem. Even though treatment and therapeutic approaches to cancer have become better and there has been great improvement in the diagnosis of this group of pathologies, many cancer types are still lethal as there is no substantial treatment available. Further, even if treatment is successful, there is a significant risk of tumour recurrence, and such a tumour is then even harder to treat due to the acquired resistance in response to exposure to the initial treatment used. Cancer stem cells (CSCs) have been suggested as a reason behind more resistant tumours and tumour recurrence. Hence, CSCs are emerging as an important target for chemotherapy in order to suppress the re-initiation of tumours. The work of this laboratory has focused on two mitocans (mitochondrially-targeted anti-cancer compounds), α-tocopheryl succinate and its mitochondrially targeted derivative MitoVES. These anti-cancer agents have been shown to be effective against a variety of cancer cells and several in vivo mouse models of cancer, while being non-toxic to normal tissue. Whether they are able to target CSCs was one of the main aims of this study. This thesis addresses several questions in regards to CSCs. Firstly, breast and prostate cancer cell lines (MCF7 and LNCaP, respectively) and a mesothelioma cell line (IstMes2) as well as primary glioblastoma cells grown in the form of spheres were confirmed as a valid model to study CSC biology and resistance to apoptosis, as both phenotypical and genotypical features confirmed increased levels of stemness.
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    Thesis Type
    Thesis (PhD Doctorate)
    Degree Program
    Doctor of Philosophy (PhD)
    School
    School of Medical Science
    DOI
    https://doi.org/10.25904/1912/1607
    Copyright Statement
    The author owns the copyright in this thesis, unless stated otherwise.
    Item Access Status
    Public
    Note
    In order to comply with copyright the: Chapters 3, 4, 5 and 6 and Figures 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 14, 15, 16, 17, 18, 19, 20, 21, 24, 25, 26, 27, and 28 and Tables 1 and 7 have been removed from this copy.
    Subject
    Cancer
    Cancer stem cells
    Mesothelioma
    Prostate Cancer
    Breast cancer
    Publication URI
    http://hdl.handle.net/10072/367971
    Collection
    • Theses - Higher Degree by Research

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