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dc.contributor.advisorMahalingam, Suresh
dc.contributor.authorChen, Weiqiang
dc.date.accessioned2018-01-23T02:58:04Z
dc.date.available2018-01-23T02:58:04Z
dc.date.issued2015
dc.identifier.doi10.25904/1912/1074
dc.identifier.urihttp://hdl.handle.net/10072/367986
dc.description.abstractArthritogenic alphaviruses such as Ross River virus (RRV) and chikungunya (CHIKV), Sindbis-like viruses (SINV), Barmah Forest virus (BFV), ) Mayaro virus (MAYV) and o’nyong-nyong virus (ONNV) are responsible for outbreaks of debilitating rheumatic joint disease during infection. CHIKV is typically notorious in central Africa, India, South-East Asia and Europe, while other alphaviruses such as RRV and BFV are endemic to Australia. In Australia, there are approximately 4000 cases of RRV reported annually, while the number of CHIKV cases continues to rise in epidemic regions. In 2014, CHIKV invaded several Caribbean islands in the Americas, with a current estimated 1.1 million autochthonous transmission cases as of 16th January 2015. During disease outbreak, more than 95% of patients experience intense persisting pain, generally in knees and the joints of extremeties. Despite the high occurrence rheumatic joint symptoms during alphavirus infection, there are limited studies on the skeletal pathologies due to the lack of routine clinical surveillance. Hence, very little is known about the impact of alphavirus infection on the bone remodelling process and warrants further investigation.
dc.languageEnglish
dc.publisherGriffith University
dc.publisher.placeBrisbane
dc.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
dc.subject.keywordsArthritogenic alphaviruses
dc.subject.keywordsRoss River virus (RRV)
dc.subject.keywordsChikungunya (CHIKV)
dc.subject.keywordsSindbis-like viruses (SINV)
dc.subject.keywordsBarmah Forest virus (BFV)
dc.subject.keywordsMayaro virus (MAYV)
dc.subject.keywordsO’nyong-nyong virus (ONNV)
dc.subject.keywordsInflammatory Arthritis
dc.titleThe Interplay between Alphaviral Infection and Inflammatory Arthritis
dc.typeGriffith thesis
gro.facultyScience, Environment, Engineering and Technology
gro.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
gro.hasfulltextFull Text
dc.contributor.otheradvisorHerrero, Lara
dc.contributor.otheradvisorSheng, Kuo-Ching
dc.contributor.otheradvisorRulli, Nestor
dc.rights.accessRightsPublic
gro.identifier.gurtIDgu1452832267407
gro.source.ADTshelfnoADT0
gro.source.GURTshelfnoGURT
gro.thesis.degreelevelThesis (PhD Doctorate)
gro.thesis.degreeprogramDoctor of Philosophy (PhD)
gro.departmentInstitute for Glycomics
gro.griffith.authorChen, Javier


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