An Investigation into Gilbert’s Syndrome: Understanding the Role of Unconjugated Bilirubin in Targeting Platelet and Haemostatic Mechanisms Associated with Thrombotic Risk Factors

View/ Open
Author(s)
Primary Supervisor
Singh, Indu
Other Supervisors
Bulmer, Andrew
Year published
2017
Metadata
Show full item recordAbstract
Gilbert’s syndrome (GS) is a common genetic condition associated with mildly elevated unconjugated bilirubin (UCB) concentrations and increased protection against development of cardiovascular disease (CVD). Mutation in the uridine diphosphate glucuronosyltransferase (UGT1A1) gene causing a reduction in UGT1A1 enzyme activity that is responsible for conjugation and elimination of UCB, is considered as the cause for GS. Numerous studies have shown that elevated levels of UCB are negatively associated with risk of developing CVD. While, several in vitro and in vivo trials have shown that UCB at physiological concentrations can ...
View more >Gilbert’s syndrome (GS) is a common genetic condition associated with mildly elevated unconjugated bilirubin (UCB) concentrations and increased protection against development of cardiovascular disease (CVD). Mutation in the uridine diphosphate glucuronosyltransferase (UGT1A1) gene causing a reduction in UGT1A1 enzyme activity that is responsible for conjugation and elimination of UCB, is considered as the cause for GS. Numerous studies have shown that elevated levels of UCB are negatively associated with risk of developing CVD. While, several in vitro and in vivo trials have shown that UCB at physiological concentrations can improve endothelial function, lipid profile and reduce vascular inflammation, thereby imparting its cardiovascular protection. Cardiovascular disease is a major cause of death globally, an estimated 17.3 million CVD related deaths are reported annually by the World Health Organization (WHO), making it the largest cause of human mortality. Furthermore, several studies have predicted that these numbers would continue rising in the coming years, due to factors such as aging, life style choices and environmental changes.
View less >
View more >Gilbert’s syndrome (GS) is a common genetic condition associated with mildly elevated unconjugated bilirubin (UCB) concentrations and increased protection against development of cardiovascular disease (CVD). Mutation in the uridine diphosphate glucuronosyltransferase (UGT1A1) gene causing a reduction in UGT1A1 enzyme activity that is responsible for conjugation and elimination of UCB, is considered as the cause for GS. Numerous studies have shown that elevated levels of UCB are negatively associated with risk of developing CVD. While, several in vitro and in vivo trials have shown that UCB at physiological concentrations can improve endothelial function, lipid profile and reduce vascular inflammation, thereby imparting its cardiovascular protection. Cardiovascular disease is a major cause of death globally, an estimated 17.3 million CVD related deaths are reported annually by the World Health Organization (WHO), making it the largest cause of human mortality. Furthermore, several studies have predicted that these numbers would continue rising in the coming years, due to factors such as aging, life style choices and environmental changes.
View less >
Thesis Type
Thesis (PhD Doctorate)
Degree Program
Doctor of Philosophy (PhD)
School
School of Medical Science
Copyright Statement
The author owns the copyright in this thesis, unless stated otherwise.
Subject
Gilbert’s syndrome
Unconjugated bilirubin
Uridine diphosphate glucuronosyltransferase (UGT1A1)
Thrombotic risk factors