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dc.contributor.authorDissanayaka, Nadeeka NW
dc.contributor.authorSellbach, Anna
dc.contributor.authorMatheson, Sally
dc.contributor.authorO'Sullivan, John D
dc.contributor.authorSilburn, Peter A
dc.contributor.authorByrne, Gerard J
dc.contributor.authorMarsh, Rodney
dc.contributor.authorMellick, George D
dc.date.accessioned2017-05-03T11:47:03Z
dc.date.available2017-05-03T11:47:03Z
dc.date.issued2010
dc.date.modified2011-03-07T08:51:59Z
dc.identifier.issn0885-3185
dc.identifier.doi10.1002/mds.22833
dc.identifier.urihttp://hdl.handle.net/10072/36823
dc.description.abstractAnxiety disorders are common in Parkinson's disease (PD) patients, yet are poorly studied. We examined the prevalence of anxiety disorders in PD, investigated the association between anxiety, and presentation and progression of PD, and studied for the first time the contribution of putative risk factors for anxiety in PD. A case-series of 79 PD patients recruited from neurology out-patient clinics was examined for anxiety disorders using the DSM-IV criteria. The Unified Parkinson's Disease Rating Scale and the Hoehn and Yahr Staging of PD were employed to understand the relationship between anxiety disorders, and the clinical presentation and severity of PD. A validated survey assessed putative risk factors for anxiety in PD. Twenty-five percent of PD patients were diagnosed with anxiety. Panic disorder, generalised anxiety disorder and social phobia were prevalent anxiety disorders. Comorbid depression with anxiety was observed (14%). The severity but not the duration of PD was positively related to anxiety. PD patients with postural instability and gait dysfunction symptom clustering were more likely to experience anxiety than tremor-dominant patients. While levodopa dosage had no relationship to anxiety, experience of dyskinesias or on/off fluctuations increased the risk. Lateralisation of PD had no association with anxiety. Anxiety disorders decreased with age and young onset PD patients were more likely to experience anxiety than the late onset subjects. Anxiety adds to the complexity of PD, lowering patients' quality of life. Future research can be directed to identify reactive and organic nature of anxiety in PD. 頲010 Movement Disorder Society
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_AU
dc.publisherJohn Wiley & Sons
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom838
dc.relation.ispartofpageto845
dc.relation.ispartofissue7
dc.relation.ispartofjournalMovement Disorders
dc.relation.ispartofvolume25
dc.rights.retentionY
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchHuman Movement and Sports Sciences
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchcode110399
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1106
dc.subject.fieldofresearchcode1702
dc.titleAnxiety disorders in Parkinson's disease: Prevalence and risk factors
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorSilburn, Peter A.
gro.griffith.authorMellick, George
gro.griffith.authorDissanayaka, Nadeeka


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