Show simple item record

dc.contributor.authorDissanayaka, Nadeeka NW
dc.contributor.authorAu, Tiffany R
dc.contributor.authorAngwin, Anthony J
dc.contributor.authorO'Sullivan, John D
dc.contributor.authorByrne, Gerard J
dc.contributor.authorSilburn, Peter A
dc.contributor.authorMarsh, Rodney
dc.contributor.authorMellick, George D
dc.contributor.authorCopland, David A
dc.date.accessioned2018-01-24T05:44:28Z
dc.date.available2018-01-24T05:44:28Z
dc.date.issued2017
dc.identifier.issn0894-4105
dc.identifier.doi10.1037/neu0000333
dc.identifier.urihttp://hdl.handle.net/10072/368351
dc.description.abstractObjective: Emotional and cognitive disturbances are common complications in Parkinson’s disease (PD). N400 is an event related potential (ERP) strongly linked to lexical-semantic processing and has demonstrated alterations in amplitude and latency when PD patients performed semantic priming tasks. The present study investigated the role of N400 in an automatic affective priming paradigm in PD. Other ERP components relevant to emotion processing were also examined. Method: Twenty-two PD patients and 17 healthy adults performed an automatic affective priming task while ERPs were recorded using 128 channels. Prime–target word pairs of negative or neutral valence were presented at a stimulus onset asynchrony of 250 ms. Participants were asked to evaluate the valence of the target word by button press. Results: A larger N400 amplitude for incongruent compared with congruent neutral targets was observed at right central and parietal regions and did not differ between PD and controls. PD and controls also displayed larger P300 and late positive potential (LPP) amplitudes for negative compared with neutral targets at central parietal and right frontal regions. In contrast, whereas controls showed a larger slow negative wave (SNW) for negative targets compared with neutral targets at left frontal and left central regions, PD group demonstrated a significant reduction in SNW amplitude difference at the left central region. Conclusion: N400 is intact in PD when processing evaluative judgments of emotional words. P300 and LPP were also intact in PD. The altered left central SNW in PD suggests an ERP marker for emotional dysfunction in PD. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherJohn Wiley & Sons
dc.relation.ispartofpagefrom585
dc.relation.ispartofpageto595
dc.relation.ispartofissue6
dc.relation.ispartofjournalJournal of Neuropsychology
dc.relation.ispartofvolume31
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchNeurosciences not elsewhere classified
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode320999
dc.subject.fieldofresearchcode52
dc.subject.fieldofresearchcode5204
dc.titleN400 and Emotional Word Processing in Parkinson's Disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorMellick, George


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record