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dc.contributor.authorKim, Nam Heeen_US
dc.contributor.authorPham, Ngocen_US
dc.contributor.authorQuinn, Ronalden_US
dc.contributor.authorKwon, Ho Jeongen_US
dc.date.accessioned2017-05-03T11:47:06Z
dc.date.available2017-05-03T11:47:06Z
dc.date.issued2010en_US
dc.date.modified2011-03-07T08:52:41Z
dc.identifier.issn0006291Xen_US
dc.identifier.doi10.1016/j.bbrc.2010.07.025en_AU
dc.identifier.urihttp://hdl.handle.net/10072/36840
dc.description.abstractR-(-)-߭O-methylsynephrine (OMe-Syn) is an active compound isolated from a plant of the Rutaceae family. We conducted cell proliferation assays on various cell lines and found that OMe-Syn more strongly inhibited the growth of human umbilical vein endothelial cells (HUVECs) than that of other normal and cancer cell lines tested. In angiogenesis assays, it inhibited vascular endothelial growth factor (VEGF)-induced invasion and tube formation of HUVECs with no toxicity. The anti-angiogenic activity of OMe-Syn was also validated in vivo using the chorioallantonic membrane (CAM) assay in growing chick embryos. Expression of the growth factors VEGF, hepatocyte growth factor, and basic fibroblast growth factor was suppressed by OMe-Syn in a dose-dependent manner. Taken together, our results indicate that this compound could be a novel basis for a small molecule targeting angiogenesisen_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom20en_US
dc.relation.ispartofpageto23en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalBiochemical and Biophysical Research Communicationsen_US
dc.relation.ispartofvolume399en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchBiologically Active Moleculesen_US
dc.subject.fieldofresearchcode030401en_US
dc.titleR-(–)-β-O-methylsynephrine, a natural product, inhibits VEGF-induced angiogenesis in vitro and in vivoen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2010
gro.hasfulltextNo Full Text


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