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dc.contributor.authorStewart, Romal
dc.contributor.authorWali, Gautam
dc.contributor.authorPerry, Chris
dc.contributor.authorLavin, Martin F
dc.contributor.authorFeron, Francois
dc.contributor.authorMackay-Sim, Alan
dc.contributor.authorSutharsan, Ratneswary
dc.contributor.editorKozlov, SV
dc.date.accessioned2018-10-12T01:32:28Z
dc.date.available2018-10-12T01:32:28Z
dc.date.issued2017
dc.identifier.isbn978-1-4939-6953-1
dc.identifier.doi10.1007/978-1-4939-6955-5_28
dc.identifier.urihttp://hdl.handle.net/10072/368444
dc.description.abstractThe molecular pathogenesis of ataxia-telangiectasia (A-T) is not yet fully understood, and a versatile cellular model is required for in vitro studies. The occurrence of continuous neurogenesis and easy access make the multipotent adult stem cells from the olfactory mucosa within the nasal cavity a potential cellular model. We describe an efficient method to establish neuron-like cells from olfactory mucosa biopsies derived from A-T patients for the purpose of studying the cellular and molecular aspects of this debilitating disease.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer New York
dc.publisher.placeUnited States
dc.relation.ispartofbooktitleATM Kinase: Methods and Protocols
dc.relation.ispartofchapter28
dc.relation.ispartofpagefrom391
dc.relation.ispartofpageto400
dc.subject.fieldofresearchOther chemical sciences
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchGenetics not elsewhere classified
dc.subject.fieldofresearchcode3499
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode310599
dc.titleA Patient-Specific Stem Cell Model to Investigate the Neurological Phenotype Observed in Ataxia-Telangiectasia
dc.typeBook chapter
dc.type.descriptionB1 - Chapters
dc.type.codeB - Book Chapters
gro.hasfulltextNo Full Text
gro.griffith.authorMackay-Sim, Alan


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