A Bastadin with Potent and Selective δ-Opioid Receptor Binding Affinity from the Australian Sponge Ianthella flabelliformis
Author(s)
Carroll, Anthony R
Kaiser, Sonya M
Davis, Rohan A
Moni, Roger W
Hooper, John NA
Quinn, Ronald J
Year published
2010
Metadata
Show full item recordAbstract
Three new bastadins, bastadin 25 (1), 15-O-sulfonatobastadin 11 (2), and bastadin 26 (3), were isolated from a MeOH extract of the Australian marine sponge Ianthella flabelliformis. Their structures were determined by interpretation of 1D and 2D NMR spectra and mass spectrometry. Bastadin 26 (3) showed potent affinity for the guinea pig d-opioid receptors with a Ki value of 100 nM. The other two bastadins had a 100-fold lower affinity. The three compounds were also tested for their affinity to guinea pig 孠and ?-opioid receptors and shown to have either no affinity or only very weak affinity toward both of these opioid receptors.Three new bastadins, bastadin 25 (1), 15-O-sulfonatobastadin 11 (2), and bastadin 26 (3), were isolated from a MeOH extract of the Australian marine sponge Ianthella flabelliformis. Their structures were determined by interpretation of 1D and 2D NMR spectra and mass spectrometry. Bastadin 26 (3) showed potent affinity for the guinea pig d-opioid receptors with a Ki value of 100 nM. The other two bastadins had a 100-fold lower affinity. The three compounds were also tested for their affinity to guinea pig 孠and ?-opioid receptors and shown to have either no affinity or only very weak affinity toward both of these opioid receptors.
View less >
View less >
Journal Title
Journal of Natural Products
Volume
73
Issue
6
Copyright Statement
Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
Subject
Chemical sciences
Biologically active molecules
Biological sciences
Biomedical and clinical sciences
Traditional, complementary and integrative medicine