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  • A Bastadin with Potent and Selective δ-Opioid Receptor Binding Affinity from the Australian Sponge Ianthella flabelliformis

    Author(s)
    Carroll, Anthony R
    Kaiser, Sonya M
    Davis, Rohan A
    Moni, Roger W
    Hooper, John NA
    Quinn, Ronald J
    Griffith University Author(s)
    Quinn, Ronald J.
    Davis, Rohan A.
    Carroll, Anthony R.
    Year published
    2010
    Metadata
    Show full item record
    Abstract
    Three new bastadins, bastadin 25 (1), 15-O-sulfonatobastadin 11 (2), and bastadin 26 (3), were isolated from a MeOH extract of the Australian marine sponge Ianthella flabelliformis. Their structures were determined by interpretation of 1D and 2D NMR spectra and mass spectrometry. Bastadin 26 (3) showed potent affinity for the guinea pig d-opioid receptors with a Ki value of 100 nM. The other two bastadins had a 100-fold lower affinity. The three compounds were also tested for their affinity to guinea pig 孠and ?-opioid receptors and shown to have either no affinity or only very weak affinity toward both of these opioid receptors.Three new bastadins, bastadin 25 (1), 15-O-sulfonatobastadin 11 (2), and bastadin 26 (3), were isolated from a MeOH extract of the Australian marine sponge Ianthella flabelliformis. Their structures were determined by interpretation of 1D and 2D NMR spectra and mass spectrometry. Bastadin 26 (3) showed potent affinity for the guinea pig d-opioid receptors with a Ki value of 100 nM. The other two bastadins had a 100-fold lower affinity. The three compounds were also tested for their affinity to guinea pig 孠and ?-opioid receptors and shown to have either no affinity or only very weak affinity toward both of these opioid receptors.
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    Journal Title
    Journal of Natural Products
    Volume
    73
    Issue
    6
    DOI
    https://doi.org/10.1021/np100010z
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
    Subject
    Chemical sciences
    Biologically active molecules
    Biological sciences
    Biomedical and clinical sciences
    Traditional, complementary and integrative medicine
    Publication URI
    http://hdl.handle.net/10072/36859
    Collection
    • Journal articles

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