Solid-Phase O-Glycosylation with a Glucosamine Derivative for the Synthesis of a Glycopeptide
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An efficient synthesis of the O-linked glycosylamino acid Fmoc–L-Ser((Ac)3–β-D-GlcNAc)-OH building block is described. The utility of the method was demonstrated with direct solid-phase O-glycosylation of the hydroxyl group on the amino acid (Ser) side chain of a human α-A crystallin-derived peptide (AIPVSREEK) in nearly quantitative glycosylation yield.
Australian Journal of Chemistry
Analytical Chemistry not elsewhere classified