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dc.contributor.authorBoehm, Raphael
dc.contributor.authorFreiberger, Friedrich
dc.contributor.authorStummeyer, Katharina
dc.contributor.authorGerardy-Schahn, Rita
dc.contributor.authorvon Itzstein, Mark
dc.contributor.authorHaselhorst, Thomas
dc.date.accessioned2017-05-03T11:47:35Z
dc.date.available2017-05-03T11:47:35Z
dc.date.issued2010
dc.date.modified2011-03-07T08:54:03Z
dc.identifier.issn1439-4227
dc.identifier.doi10.1002/cbic.200900659
dc.identifier.urihttp://hdl.handle.net/10072/36880
dc.description.abstractOn the loose: We report an STD NMR spectroscopic study of the polysialyltransferase from Neisseria meningitidis serogroup B (NmB-polyST). The spectra reveal that the cytosine and ribose moiety receive more saturation than the sialic acid residue of CMP-Neu5Ac. This loose binding enables a fast and efficient sialyl transfer to the acceptor substrate. Our analysis offers a view of the structural determinants necessary for binding to NmB-polyST that provide the basis for the development of novel NmB-polyST inhibitors.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-VCH Verlag
dc.publisher.placeGermany
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom170
dc.relation.ispartofpageto174
dc.relation.ispartofissue2
dc.relation.ispartofjournalChemBioChem
dc.relation.ispartofvolume11
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchMedical biochemistry and metabolomics not elsewhere classified
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode320599
dc.titleNeisseria meningitidis Serogroup B Polysialyltransferase: Insights into Substrate Binding
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomics
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorvon Itzstein, Mark
gro.griffith.authorHaselhorst, Thomas E.


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