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dc.contributor.authorAbdal-hay, Abdalla
dc.contributor.authorBartnikowski, Michal
dc.contributor.authorHamlet, Stephen
dc.contributor.authorIvanovski, Saso
dc.date.accessioned2019-07-04T12:38:07Z
dc.date.available2019-07-04T12:38:07Z
dc.date.issued2018
dc.identifier.issn0928-4931
dc.identifier.doi10.1016/j.msec.2017.08.041
dc.identifier.urihttp://hdl.handle.net/10072/368875
dc.description.abstractPolymer scaffolds produced through an electrospinning process are frequently explored as tissue substitutes for regenerative medicine. Despite offering desirable surface area to volume ratios and tailorable pore sizes, their poor structural mechanical properties limit their applicability in load-bearing regions. In this study, we present a simple strategy to improve the mechanical properties of a vascular graft scaffold. We achieved the formation of biphasic tubular scaffolds by electrospinning polyurethane (PU) onto an airbrushed tube made of polycaprolactone (PCL). After preparation, the scaffold was subsequently thermally-crosslinked (60 °C) to strengthen the bonding between the two materials. The tensile strength and tensile elastic (Young's) modulus of the biphasic scaffolds were significantly enhanced from 4.5 ± 1.72 and 45 ± 15 MPa (PU-only) up to 67.5 ± 2.4 and 1039 ± 81.8 MPa (PCL/PU; p < 0.05). Additionally, suture retention force, burst pressure, and compliance were all improved. The cytotoxicity of the fabricated samples was investigated using an MTT assay after 7 days of cell culture and found to be negligible (~ 100% viability). In conclusion, we have demonstrated the preparation and characterization of a stable and mechanically robust vascular graft scaffold using a novel combination of well-established fabrication techniques. This study could also be extended to the fabrication of other biphasic scaffolds to better enhance the mechanical properties of the electrospun fibers mat without deteriorating its architecture structure.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeSwitzerland
dc.relation.ispartofpagefrom10
dc.relation.ispartofpageto18
dc.relation.ispartofjournalMaterials Science and Engineering C: Biomimetic Materials, Sensors and Systems
dc.relation.ispartofvolume82
dc.subject.fieldofresearchMacromolecular and Materials Chemistry not elsewhere classified
dc.subject.fieldofresearchBiomedical Engineering
dc.subject.fieldofresearchMaterials Engineering
dc.subject.fieldofresearchcode030399
dc.subject.fieldofresearchcode0903
dc.subject.fieldofresearchcode0912
dc.titleElectrospun biphasic tubular scaffold with enhanced mechanical properties for vascular tissue engineering
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Dentistry and Oral Health
gro.hasfulltextNo Full Text
gro.griffith.authorHamlet, Stephen
gro.griffith.authorIvanovski, Saso
gro.griffith.authorBartnikowski, Michal
gro.griffith.authorAli, Abdalla A.


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