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dc.contributor.authorPlatts, David G
dc.contributor.authorBartnikowski, Nicole
dc.contributor.authorGregory, Shaun D
dc.contributor.authorScalia, Gregory M
dc.contributor.authorFraser, John F
dc.date.accessioned2018-02-06T03:47:07Z
dc.date.available2018-02-06T03:47:07Z
dc.date.issued2017
dc.identifier.issn2314-6133
dc.identifier.doi10.1155/2017/4907898
dc.identifier.urihttp://hdl.handle.net/10072/368887
dc.description.abstractObjectives. Transthoracic echocardiography (TTE) is fundamental in managing patients supported with ventricular assist devices (VAD). However imaging can be difficult in these patients. Contrast improves image quality but they are hydrodynamically fragile agents. The aim was to assess contrast concentration following passage through a VAD utilising a mock circulation loop (MCL). Methods. Heartware continuous flow (CF) VAD was incorporated into a MCL. Definity® contrast was infused into the MCL with imaging before and after CF-VAD. 5 mm2 regions of interest were used to obtain signal intensity (decibels), as a surrogate of contrast concentration. Results. Four pump speeds revealed significant reduction in contrast signal intensity after CF-VAD compared to before CF-VAD (all ). Combined pre- and postpump data at all speeds showed a 22.2% absolute reduction in contrast signal intensity across the CF-VAD (14.8 ± 0.8 dB prepump versus 11.6 ± 1.4 dB postpump; ). Mean signal intensity reduction at each speed showed an inverse relationship between speed and relative reduction in signal intensity. Conclusion. Contrast microsphere transit through a CF-VAD within a MCL resulted in significant reduction in signal intensity, consistent with destruction within the pump. This was evident at all CF-VAD pump speeds but relative signal drop was inversely proportional to pump speed.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherHindawi Publishing
dc.relation.ispartofpagefrom4907898-1
dc.relation.ispartofpageto4907898-9
dc.relation.ispartofjournalBioMed Research International
dc.relation.ispartofvolume2017
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchNanobiotechnology
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode310607
dc.titleContrast Microsphere Destruction by a Continuous Flow Ventricular Assist Device: An In Vitro Evaluation Using a Mock Circulation Loop
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2017 David G. Platts et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorGregory, Shaun D.
gro.griffith.authorFraser, John F.


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