• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Book chapters
    • View Item
    • Home
    • Griffith Research Online
    • Book chapters
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • The MIF-CD74 Inflammatory Axis in Alphaviral Infection

    Author
    Herrero, Lara
    Zaid, Ali
    Mutso, Margit
    Mahalingam, Suresh
    Year published
    2017
    Metadata
    Show full item record
    Abstract
    The expansion of mosquito-borne viral (arboviral) arthritis poses a significant threat to human health worldwide. Clinical reports show that arboviral arthritis can be persistent and debilitating, with evidence of bone pathology. As part of the Togaviridae family, alphaviruses are mosquito-borne viruses that are widely distributed throughout the globe causing extensive morbidity and mortality. Despite this, very little is known about the pathogenesis of disease caused by alphaviruses. It has been shown that macrophages play a crucial role in the development of alphaviral arthritis. Infection causes macrophage activation and ...
    View more >
    The expansion of mosquito-borne viral (arboviral) arthritis poses a significant threat to human health worldwide. Clinical reports show that arboviral arthritis can be persistent and debilitating, with evidence of bone pathology. As part of the Togaviridae family, alphaviruses are mosquito-borne viruses that are widely distributed throughout the globe causing extensive morbidity and mortality. Despite this, very little is known about the pathogenesis of disease caused by alphaviruses. It has been shown that macrophages play a crucial role in the development of alphaviral arthritis. Infection causes macrophage activation and the release of macrophage inhibitory factor (MIF), which subsequently plays a pivotal role in alphavirus-induced arthritis by regulating the expression of pro-inflammatory factors. This chapter discusses the role of the MIF-CD74 axis in the development of alphavirus arthritis and the therapeutic potential of antagonists in the treatment of alphaviral arthropathies.
    View less >
    Book Title
    MIF Family Cytokines in Innate Immunity and Homeostasis
    DOI
    https://doi.org/10.1007/978-3-319-52354-5_11
    Subject
    Infectious Diseases
    Publication URI
    http://hdl.handle.net/10072/369057
    Collection
    • Book chapters

    Footer

    Social media

    • Facebook
    • Twitter
    • YouTube
    • Instagram
    • Linkedin
    First peoples of Australia
    • Aboriginal
    • Torres Strait Islander

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E

    Tagline

    • Gold Coast
    • Logan
    • Brisbane
    • Australia