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dc.contributor.authorSmith, Tai M
dc.contributor.authorSuzuki, Shuko
dc.contributor.authorCronin, Brendan G
dc.contributor.authorHaghighatpanah, Mohammadreza
dc.contributor.authorPetcu, Eugen B
dc.contributor.authorPhilippa, Christopher J
dc.contributor.authorChirila, Traian V
dc.date.accessioned2019-05-29T12:31:35Z
dc.date.available2019-05-29T12:31:35Z
dc.date.issued2018
dc.identifier.issn0740-9303
dc.identifier.doi10.1097/IOP.0000000000001063
dc.identifier.urihttp://hdl.handle.net/10072/369363
dc.description.abstractPurpose: An experimental study to demonstrate in animal eyelids that the controlled exposure of excised tarsal plate to ultraviolet-A radiation can induce a rigidification effect due to photochemical crosslinking of the constitutive collagen. Methods: Excised strips of sheep tarsus were irradiated with ultraviolet-A rays (wavelength 365 nm) at low and high irradiances, in the presence of riboflavin as a photosensitizer, using radiation sources available for corneal collagen crosslinking procedure. The tensile strength and Young’s modulus (stiffness) of irradiated and control samples were measured in a mechanical tester and analyzed statistically. Histologic examination of the specimens was carried out to evaluate the effect of radiation on the meibomian glands and collagen organization. Results: Mechanical evaluation showed that irradiation induced both stiffening and strengthening of the tarsal plate specimens, and this effect was enhanced at the higher levels of irradiance. The changes in mechanical properties can be attributed to a process of photochemically induced crosslinking of tarsal collagen. Histology revealed no changes in the meibomian glands or in the fibrous collagen system of the tarsus. Conclusions: These findings indicate that irradiation of tarsal collagen leading to tissue stiffening could be a safe procedure for treating lax eyelid conditions in human patients.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto6
dc.relation.ispartofjournalOphthalmic Plastic and Reconstructive Surgery
dc.subject.fieldofresearchOphthalmology and optometry
dc.subject.fieldofresearchOphthalmology
dc.subject.fieldofresearchcode3212
dc.subject.fieldofresearchcode321201
dc.titlePhotochemically Induced Crosslinking of Tarsal Collagen as a Treatment for Eyelid Laxity: Assessing Potentiality in Animal Tissue
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.hasfulltextNo Full Text
gro.griffith.authorPetcu, Eugen B.
gro.griffith.authorPhilippa, Christopher J.


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