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dc.contributor.authorWang, Quan-Xin
dc.contributor.authorYang, Jian-Ling
dc.contributor.authorQi, Qiu-Yue
dc.contributor.authorBao, Li
dc.contributor.authorYang, Xiao-Li
dc.contributor.authorLiu, Miao-Miao
dc.contributor.authorHuang, Pei
dc.contributor.authorZhang, Li-Xin
dc.contributor.authorChen, Ji-Long
dc.contributor.authorCai, Lei
dc.contributor.authorLiu, Hong-Wei
dc.date.accessioned2018-02-19T12:30:28Z
dc.date.available2018-02-19T12:30:28Z
dc.date.issued2013
dc.identifier.issn0960-894X
dc.identifier.doi10.1016/j.bmcl.2013.04.034
dc.identifier.urihttp://hdl.handle.net/10072/369395
dc.description.abstractA new ophiobolin derivative, 3-anhydro-6-hydroxy-ophiobolin A (1), as well as two known ophiobolin derivatives 3-anhydro-ophiobolin A (2) and 3-anhydro-6-epi-ophiobolin A (3) were isolated from the PDB culture of a phytopathogenic fungus Bipolaris oryzae. The structure of 1 was elucidated through 2D NMR and other spectroscopic techniques. Compound 1 exhibited strong antimicrobial activity against Bacille Calmette–Guerin, Bacillus subtilis, Staphylococcus aureus, and methicillin-resistant Staphylococcus aureus with MIC value of 12.5 μg/mL, and potent antiproliferative activity against cell lines HepG2 and K562 with IC50 of 6.49 μM and 4.06 μM, respectively. Further studies on the cytotoxicity of compound 1 against K562 cells demonstrated that it induced apoptosis, observed by flow cytometric method. Preliminary structure–activity relationships of these ophiobolins and the mechanism of apoptosis induced by 1 were analyzed.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom3547
dc.relation.ispartofpageto3550
dc.relation.ispartofjournalBioorganic & Medicinal Chemistry Letters
dc.relation.ispartofvolume23
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchMedicinal and biomolecular chemistry not elsewhere classified
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode340499
dc.subject.fieldofresearchcode3405
dc.subject.fieldofresearchcode3214
dc.title3-Anhydro-6-hydroxy-ophiobolin A, a new sesterterpene inhibiting the growth of methicillin-resistant Staphylococcus aureus and inducing the cell death by apoptosis on K562, from the phytopathogenic fungus Bipolaris oryzae
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorLiu, Miaomiao


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