dc.contributor.author | Wang, Quan-Xin | |
dc.contributor.author | Yang, Jian-Ling | |
dc.contributor.author | Qi, Qiu-Yue | |
dc.contributor.author | Bao, Li | |
dc.contributor.author | Yang, Xiao-Li | |
dc.contributor.author | Liu, Miao-Miao | |
dc.contributor.author | Huang, Pei | |
dc.contributor.author | Zhang, Li-Xin | |
dc.contributor.author | Chen, Ji-Long | |
dc.contributor.author | Cai, Lei | |
dc.contributor.author | Liu, Hong-Wei | |
dc.date.accessioned | 2018-02-19T12:30:28Z | |
dc.date.available | 2018-02-19T12:30:28Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0960-894X | |
dc.identifier.doi | 10.1016/j.bmcl.2013.04.034 | |
dc.identifier.uri | http://hdl.handle.net/10072/369395 | |
dc.description.abstract | A new ophiobolin derivative, 3-anhydro-6-hydroxy-ophiobolin A (1), as well as two known ophiobolin derivatives 3-anhydro-ophiobolin A (2) and 3-anhydro-6-epi-ophiobolin A (3) were isolated from the PDB culture of a phytopathogenic fungus Bipolaris oryzae. The structure of 1 was elucidated through 2D NMR and other spectroscopic techniques. Compound 1 exhibited strong antimicrobial activity against Bacille Calmette–Guerin, Bacillus subtilis, Staphylococcus aureus, and methicillin-resistant Staphylococcus aureus with MIC value of 12.5 μg/mL, and potent antiproliferative activity against cell lines HepG2 and K562 with IC50 of 6.49 μM and 4.06 μM, respectively. Further studies on the cytotoxicity of compound 1 against K562 cells demonstrated that it induced apoptosis, observed by flow cytometric method. Preliminary structure–activity relationships of these ophiobolins and the mechanism of apoptosis induced by 1 were analyzed. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofpagefrom | 3547 | |
dc.relation.ispartofpageto | 3550 | |
dc.relation.ispartofjournal | Bioorganic & Medicinal Chemistry Letters | |
dc.relation.ispartofvolume | 23 | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry not elsewhere classified | |
dc.subject.fieldofresearch | Organic chemistry | |
dc.subject.fieldofresearch | Pharmacology and pharmaceutical sciences | |
dc.subject.fieldofresearchcode | 3404 | |
dc.subject.fieldofresearchcode | 340499 | |
dc.subject.fieldofresearchcode | 3405 | |
dc.subject.fieldofresearchcode | 3214 | |
dc.title | 3-Anhydro-6-hydroxy-ophiobolin A, a new sesterterpene inhibiting the growth of methicillin-resistant Staphylococcus aureus and inducing the cell death by apoptosis on K562, from the phytopathogenic fungus Bipolaris oryzae | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Liu, Miaomiao | |