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dc.contributor.authorParlane, Natalie A
dc.contributor.authorGupta, Sandeep K
dc.contributor.authorRubio-Reyes, Patricia
dc.contributor.authorChen, Shuxiong
dc.contributor.authorGonzalez-Miro, Majela
dc.contributor.authorWedlock, D Neil
dc.contributor.authorRehm, Bernd HA
dc.date.accessioned2018-02-28T23:38:35Z
dc.date.available2018-02-28T23:38:35Z
dc.date.issued2017
dc.identifier.issn2373-9878
dc.identifier.doi10.1021/acsbiomaterials.6b00355
dc.identifier.urihttp://hdl.handle.net/10072/370317
dc.description.abstractPolyhydroxyalkanoates (PHAs) are biological polyesters that can be naturally produced by a range of bacteria as water-insoluble inclusions composed of a PHA core coated with PHA synthesis, structural, and regulatory proteins. These naturally self-assembling shell–core particles have been recently conceived as biomaterials that can be bioengineered as biologically active beads for medical applications. Protein engineering of PHA-associated proteins enabled the production of PHA–protein assemblies exhibiting biologically active protein-based functions relevant for applications as vaccines or diagnostics. Here we provide an overview of the recent advances in bioengineering of PHA particles toward the display of biomedically relevant protein functions such as selected disease-specific antigens as diagnostic tools or for the design of particulate subunit vaccines against infectious diseases such as tuberculosis, meningitis, pneumonia, and hepatitis C.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.ispartofpagefrom3043
dc.relation.ispartofpageto3057
dc.relation.ispartofissue12
dc.relation.ispartofjournalACS Biomaterials Science and Engineering
dc.relation.ispartofvolume3
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchBiomedical engineering not elsewhere classified
dc.subject.fieldofresearchcode4003
dc.subject.fieldofresearchcode400399
dc.titleSelf-Assembled Protein-Coated Polyhydroxyalkanoate Beads: Properties and Biomedical Applications
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorRehm, Bernd
gro.griffith.authorChen, Shuxiong


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