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  • Engineering Bacillus megaterium for production of functional intracellular materials

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    Author(s)
    Grage, Katrin
    McDermott, Paul
    Rehm, Bernd HA
    Griffith University Author(s)
    Rehm, Bernd
    Year published
    2017
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    Abstract
    Over the last 10–15 years, a technology has been developed to engineer bacterial poly(3-hydroxybutyrate) (PHB) inclusions as functionalized beads, for applications such as vaccines, diagnostics and enzyme immobilization. This has been achieved by translational fusion of foreign proteins to the PHB synthase (PhaC). The respective fusion protein mediates self-assembly of PHB inclusions displaying the desired protein function. So far, beads have mainly been produced in recombinant Escherichia coli, which is problematic for some applications as the lipopolysaccharides (LPS) co-purified with such inclusions are toxic to humans ...
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    Over the last 10–15 years, a technology has been developed to engineer bacterial poly(3-hydroxybutyrate) (PHB) inclusions as functionalized beads, for applications such as vaccines, diagnostics and enzyme immobilization. This has been achieved by translational fusion of foreign proteins to the PHB synthase (PhaC). The respective fusion protein mediates self-assembly of PHB inclusions displaying the desired protein function. So far, beads have mainly been produced in recombinant Escherichia coli, which is problematic for some applications as the lipopolysaccharides (LPS) co-purified with such inclusions are toxic to humans and animals.
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    Journal Title
    Microbial Cell Factories
    Volume
    16
    Issue
    1
    DOI
    https://doi.org/10.1186/s12934-017-0823-5
    Copyright Statement
    © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
    Subject
    Microbiology
    Microbiology not elsewhere classified
    Industrial biotechnology
    Publication URI
    http://hdl.handle.net/10072/370318
    Collection
    • Journal articles

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