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  • Detection of mRNA for nuclear receptor co-activators 1 and 3 in archival breast cancer tissue and surrounding stroma: A tissue expression study

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    Author(s)
    Smith, Robert
    Gabrovska, Pam
    Lea, Rodney
    Weinstein, Stephen R.
    Griffiths, Lyn
    Griffith University Author(s)
    Griffiths, Lyn
    Lea, Rodney A.
    Smith, Robert A.
    Gabrovska, Pam
    Year published
    2010
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    Abstract
    Before the age of 75 years, approximately 10% of women will be diagnosed with breast cancer, one of the most common malignancies and a leading cause of death among women. The objective of this study was to determine if expression of the nuclear receptor coactivators 1 and 3 (NCoA1 and NCoA3) varied in breast cancer grades. RNA was extracted from 25 breast tumours and transcribed into cDNA which underwent semi-quantitative polymerase chain reaction, normalised using 18S. Analysis indicated that an expression change for NCoA1 in cancer grades and estrogen receptor alpha negative tissue (P= 0.028 and 0.001 respectively). NCoA1 ...
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    Before the age of 75 years, approximately 10% of women will be diagnosed with breast cancer, one of the most common malignancies and a leading cause of death among women. The objective of this study was to determine if expression of the nuclear receptor coactivators 1 and 3 (NCoA1 and NCoA3) varied in breast cancer grades. RNA was extracted from 25 breast tumours and transcribed into cDNA which underwent semi-quantitative polymerase chain reaction, normalised using 18S. Analysis indicated that an expression change for NCoA1 in cancer grades and estrogen receptor alpha negative tissue (P= 0.028 and 0.001 respectively). NCoA1 expression increased in grade 3 and estrogen receptor alpha negative tumours, compared to controls. NCoA3 showed a similar, but not significant, trend in grade and a non-significant decrease in estrogen receptor alpha negative tissues. Expression of NCoA1 in late stage and estrogen receptor alpha negative breast tumours may have implications to breast cancer treatment, particularly in the area of manipulation of hormone signalling systems in advanced tumours.
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    Journal Title
    The Open Breast Cancer Journal
    Volume
    2
    Publisher URI
    http://www.bentham.org/open/tobcanj/articles/V002/60TOBCANJ.htm
    Copyright Statement
    © The Author(s) 2010. For information about this journal please refer to the publisher's website or contact the authors. Articles are licensed under the terms of the Creative Commons Attribution non-commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
    Subject
    Cancer Cell Biology
    Oncology and Carcinogenesis
    Publication URI
    http://hdl.handle.net/10072/37056
    Collection
    • Journal articles

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