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dc.contributor.authorSmith, Robert
dc.contributor.authorGabrovska, Pam
dc.contributor.authorLea, Rodney
dc.contributor.authorWeinstein, Stephen R.
dc.contributor.authorGriffiths, Lyn
dc.date.accessioned2017-05-11T12:30:36Z
dc.date.available2017-05-11T12:30:36Z
dc.date.issued2010
dc.date.modified2011-03-10T08:08:32Z
dc.identifier.issn18768172
dc.identifier.urihttp://hdl.handle.net/10072/37056
dc.description.abstractBefore the age of 75 years, approximately 10% of women will be diagnosed with breast cancer, one of the most common malignancies and a leading cause of death among women. The objective of this study was to determine if expression of the nuclear receptor coactivators 1 and 3 (NCoA1 and NCoA3) varied in breast cancer grades. RNA was extracted from 25 breast tumours and transcribed into cDNA which underwent semi-quantitative polymerase chain reaction, normalised using 18S. Analysis indicated that an expression change for NCoA1 in cancer grades and estrogen receptor alpha negative tissue (P= 0.028 and 0.001 respectively). NCoA1 expression increased in grade 3 and estrogen receptor alpha negative tumours, compared to controls. NCoA3 showed a similar, but not significant, trend in grade and a non-significant decrease in estrogen receptor alpha negative tissues. Expression of NCoA1 in late stage and estrogen receptor alpha negative breast tumours may have implications to breast cancer treatment, particularly in the area of manipulation of hormone signalling systems in advanced tumours.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent802217 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherBentham Open
dc.publisher.placeNetherlands
dc.publisher.urihttp://www.bentham.org/open/tobcanj/articles/V002/60TOBCANJ.htm
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom60
dc.relation.ispartofpageto65
dc.relation.ispartofjournalThe Open Breast Cancer Journal
dc.relation.ispartofvolume2
dc.rights.retentionY
dc.subject.fieldofresearchCancer Cell Biology
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode111201
dc.subject.fieldofresearchcode1112
dc.titleDetection of mRNA for nuclear receptor co-activators 1 and 3 in archival breast cancer tissue and surrounding stroma: A tissue expression study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc/3.0/
gro.facultyGriffith Health, School of Medicine
gro.rights.copyright© The Author(s) 2010. For information about this journal please refer to the publisher's website or contact the authors. Articles are licensed under the terms of the Creative Commons Attribution non-commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.date.issued2010
gro.hasfulltextFull Text
gro.griffith.authorGriffiths, Lyn
gro.griffith.authorLea, Rodney A.
gro.griffith.authorSmith, Robert A.
gro.griffith.authorGabrovska, Pam


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