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dc.contributor.authorHui, Yue
dc.contributor.authorWibowo, David
dc.contributor.authorLiu, Yun
dc.contributor.authorRan, Rui
dc.contributor.authorWang, Hao-Fei
dc.contributor.authorSeth, Arjun
dc.contributor.authorMiddelberg, Anton PJ
dc.contributor.authorZhao, Chun-Xia
dc.date.accessioned2019-07-04T12:33:01Z
dc.date.available2019-07-04T12:33:01Z
dc.date.issued2018
dc.identifier.issn1936-0851
dc.identifier.doi10.1021/acsnano.8b00242
dc.identifier.urihttp://hdl.handle.net/10072/370765
dc.description.abstractThe physicochemical properties of nanoparticles (size, charge, and surface chemistry, etc.) influence their biological functions often in complex and poorly understood ways. This complexity is compounded when the nanostructures involved have variable mechanical properties. Here, we report the synthesis of liquid-filled silica nanocapsules (SNCs, ∼ 150 nm) having a wide range of stiffness (with Young’s moduli ranging from 704 kPa to 9.7 GPa). We demonstrate a complex trade-off between nanoparticle stiffness and the efficiencies of both immune evasion and passive/active tumor targeting. Soft SNCs showed 3 times less uptake by macrophages than stiff SNCs, while the uptake of PEGylated SNCs by cancer cells was independent of stiffness. In addition, the functionalization of stiff SNCs with folic acid significantly enhanced their receptor-mediated cellular uptake, whereas little improvement for the soft SNCs was conferred. Further in vivo experiments confirmed these findings and demonstrated the critical role of nanoparticle mechanical properties in regulating their interactions with biological systems.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto12
dc.relation.ispartofjournalACS Nano
dc.subject.fieldofresearchNanomaterials
dc.subject.fieldofresearchcode100708
dc.titleUnderstanding the effects of nanocapsular mechanical property on passive and active tumor targeting
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.rights.copyrightThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Nano, copyright 2018 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see 10.1021/acsnano.8b00242.
gro.hasfulltextFull Text
gro.griffith.authorWibowo, David


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