dc.contributor.author | Seyed Khoei, N | |
dc.contributor.author | Grindel, A | |
dc.contributor.author | Wallner, M | |
dc.contributor.author | Mölzer, C | |
dc.contributor.author | Doberer, D | |
dc.contributor.author | Marculescu, R | |
dc.contributor.author | Bulmer, A | |
dc.contributor.author | Wagner, KH | |
dc.date.accessioned | 2019-06-09T01:30:35Z | |
dc.date.available | 2019-06-09T01:30:35Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0021-9150 | |
dc.identifier.doi | 10.1016/j.atherosclerosis.2017.12.021 | |
dc.identifier.uri | http://hdl.handle.net/10072/371063 | |
dc.description.abstract | Background and aims: Mild endogenous elevation of unconjugated bilirubin (UCB) as seen in Gilbert's
syndrome (GS), might mitigate cardiovascular disease (CVD) risk factors including overweight/obesity.
This study aimed to determine whether hyperbilirubinaemia is linked to improved anthropometric data
and lipid profile.
Methods: Our study considered GS and age-/gender-matched healthy controls (n ¼ 248). Additionally,
obese female type 2 diabetic patients (DM2) (n ¼ 26) were included as a “disease control group”.
Results: BMI, hip circumference (HC), and lipid profile were significantly lower in GS. UCB was inversely
correlated with BMI (p <0 .001), HC as well as with fat mass (FM) and lipid variables (p < 0.05). Moreover,
DM2 patients had significantly lower UCB compared to GS and healthy controls. Older GS subjects (35
years) had significantly reduced anthropometric data and improved lipid profile.
Conclusions: Our results propose that the health promoting potential of mild hyperbilirubinaemia may
extend to protection from age-related weight gain and dyslipidaemia. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | Ireland | |
dc.relation.ispartofpagefrom | 306 | |
dc.relation.ispartofpageto | 311 | |
dc.relation.ispartofjournal | Atherosclerosis | |
dc.relation.ispartofvolume | 269 | |
dc.subject.fieldofresearch | Cardiovascular medicine and haematology | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearch | Clinical sciences not elsewhere classified | |
dc.subject.fieldofresearchcode | 3201 | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.fieldofresearchcode | 320299 | |
dc.title | Mild hyperbilirubinaemia as an endogenous mitigator of overweight and obesity: Implications for improved metabolic health | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.description.version | Accepted Manuscript (AM) | |
gro.rights.copyright | © 2018 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Bulmer, Andrew C. | |