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dc.contributor.authorSeyed Khoei, N
dc.contributor.authorGrindel, A
dc.contributor.authorWallner, M
dc.contributor.authorMölzer, C
dc.contributor.authorDoberer, D
dc.contributor.authorMarculescu, R
dc.contributor.authorBulmer, A
dc.contributor.authorWagner, KH
dc.date.accessioned2019-06-09T01:30:35Z
dc.date.available2019-06-09T01:30:35Z
dc.date.issued2018
dc.identifier.issn0021-9150
dc.identifier.doi10.1016/j.atherosclerosis.2017.12.021
dc.identifier.urihttp://hdl.handle.net/10072/371063
dc.description.abstractBackground and aims: Mild endogenous elevation of unconjugated bilirubin (UCB) as seen in Gilbert's syndrome (GS), might mitigate cardiovascular disease (CVD) risk factors including overweight/obesity. This study aimed to determine whether hyperbilirubinaemia is linked to improved anthropometric data and lipid profile. Methods: Our study considered GS and age-/gender-matched healthy controls (n ¼ 248). Additionally, obese female type 2 diabetic patients (DM2) (n ¼ 26) were included as a “disease control group”. Results: BMI, hip circumference (HC), and lipid profile were significantly lower in GS. UCB was inversely correlated with BMI (p <0 .001), HC as well as with fat mass (FM) and lipid variables (p < 0.05). Moreover, DM2 patients had significantly lower UCB compared to GS and healthy controls. Older GS subjects (35 years) had significantly reduced anthropometric data and improved lipid profile. Conclusions: Our results propose that the health promoting potential of mild hyperbilirubinaemia may extend to protection from age-related weight gain and dyslipidaemia.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeIreland
dc.relation.ispartofpagefrom306
dc.relation.ispartofpageto311
dc.relation.ispartofjournalAtherosclerosis
dc.relation.ispartofvolume269
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchClinical sciences not elsewhere classified
dc.subject.fieldofresearchcode3201
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode320299
dc.titleMild hyperbilirubinaemia as an endogenous mitigator of overweight and obesity: Implications for improved metabolic health
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by-nc/4.0/
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2018 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorBulmer, Andrew C.


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