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dc.contributor.authorRehm, BHA
dc.date.accessioned2018-03-13T03:02:16Z
dc.date.available2018-03-13T03:02:16Z
dc.date.issued2006
dc.identifier.issn0141-5492
dc.identifier.doi10.1007/s10529-005-5521-4
dc.identifier.urihttp://hdl.handle.net/10072/371078
dc.description.abstractPHAs (polyhydroxyalkanoates = biopolyester) composed of hydroxy fatty acids represent a rather complex class of storage polymers synthesized by various bacteria and archaea and are deposited as water-insoluble cytoplasmic nano-sized inclusions. These spherical particles are composed of a polyester core surrounded by phospholipids and proteins. The key enzymes of polyester biosynthesis and polyester particle formation are the polyester synthases, which catalyze the formation of polyesters. Various metabolic routes have been identified and established in bacteria to provide substrate for polyester synthases. Although not essential for particle formation, non-covalently attached proteins, the so-called phasins, can be found at the particle surface and are considered as structural proteins. Protein engineering of polyester synthases and phasins was used to shed light into the topology of these granule attached proteins. Biopolyesters and the respective micro-/nano-structures are currently considered as biocompatible and biodegradable biomaterials with numerous potential applications particularly in the medical field.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer Netherlands
dc.relation.ispartofpagefrom207
dc.relation.ispartofpageto213
dc.relation.ispartofissue4
dc.relation.ispartofjournalBiotechnology Letters
dc.relation.ispartofvolume28
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiochemistry and cell biology not elsewhere classified
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode310199
dc.subject.fieldofresearchcode40
dc.titleGenetics and biochemistry of polyhydroxyalkanoate granule self-assembly: The key role of polyester synthases
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorRehm, Bernd


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