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dc.contributor.authorOishi, S
dc.contributor.authorZalucki, O
dc.contributor.authorPremarathne, S
dc.contributor.authorWood, SA
dc.contributor.authorPiper, M
dc.date.accessioned2018-03-20T12:30:56Z
dc.date.available2018-03-20T12:30:56Z
dc.date.issued2016
dc.identifier.issn2326-2133
dc.identifier.doi10.1080/23262133.2016.1235524
dc.identifier.urihttp://hdl.handle.net/10072/371642
dc.description.abstractNeural stem cells (NSCs) within the adult hippocampal dentate gyrus reside in the subgranular zone (SGZ). A dynamic network of signaling mechanisms controls the balance between the maintenance of NSC identity, and their subsequent differentiation into dentate granule neurons. Recently, the ubiquitin-specific protease 9 X-linked (USP9X) was shown to be important for hippocampal morphogenesis, as mice lacking this gene exhibited a higher proportion of proliferating NSCs, yet a decrease in neuronal numbers, within the postnatal dentate gyrus. Here we reveal that Usp9x-deficiency results in the upregulation of numerous oligodendrocytic and myelin-associated genes within the postnatal hippocampus. Moreover, cell counts reveal a significant increase in oligodendrocyte precursor cells and mature oligodendrocytes per unit volume of the mutant dentate gyrus. Collectively, these findings indicate that USP9X may regulate NSC lineage determination within the postnatal SGZ.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherTaylor & Francis
dc.relation.ispartofpagefrome1235524-1
dc.relation.ispartofpagetoe1235524-9
dc.relation.ispartofissue1
dc.relation.ispartofjournalNeurogenesis
dc.relation.ispartofvolume3
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classified
dc.subject.fieldofresearchcode060199
dc.titleUSP9X deletion elevates the density of oligodendrocytes within the postnatal dentate gyrus
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorWood, Stephen A.
gro.griffith.authorPremarathne, Susitha


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